【摘要】 目的考察结直肠癌患者瘤组织中EGFR、COX-2表达及其临床意义。方法以2013至2016年在我院接受手术治疗的结直肠癌患者为研究对象,收集患者临床资料,采用免疫组化法分析肿瘤样本中EGFR、COX-2表达水平,卡方检验比较EGFR、COX-2表达与患者临床病理特征的关系。结果 EGFR表达与患者瘤径(P<0.05)、N分期显著相关(P<0.05),COX-2表达与患者Dukes分期(P<0.01)、N分期(P<0.05)、肿瘤分级显著相关(P<0.01);EGFR表达与COX-2表达显著相关(P<0.05)。结论肿瘤组织中EGFR和COX-2的表达与结直肠癌瘤组织的病理学特征显著相关,可能与结直肠癌分化和转移有关。更多还原

【Abstract】 Objective To investigate the expression of EGFR and COX-2 in tumor tissues of patients with colorectal cancer and its clinical significance. Methods Patients with colorectal cancer who underwent surgery in our hospital from 2013 to 2016 were enrolled. The clinical data of patients were collected and the expression levels of EGFR and COX-2 in tumor samples were analyzed by immunohistochemistry. The chi-square test was used to compare the relationship between EGFR and COX-2 expression and clinicopathological features. Results The expression of EGFR was significantly correlated with the tumor diameter(P< 0.05) and N stage(P< 0.05). The expression of COX-2 was significantly correlated with Dukes stage(P< 0.01), N stage(P< 0.05) and tumor grade, P< 0.01. EGFR expression was significantly associated with COX-2 expression(P< 0.05). Conclusion The expression of EGFR and COX-2 in tumor tissues is significantly correlated with the pathological features of colorectal cancer tissues, which may be related to the differentiation and metastasis of colorectal cancer.更多还原