【摘要】 目的为了分析血浆纤维蛋白原(fibrinogen,FIB)、D-二聚体和胃癌临床病理特征的关系。方法将胃癌组按分化程度、病理分期(pTNM)、浸润深度、有无淋巴结转移及体力状况评分(卡氏评分)进行分组,分别测定胃癌组和对照组(健康体检人群)的血浆FIB、D-二聚体水平,分析两者在不同分组间的差异。结果胃癌组血浆FIB、D-二聚体均显著高于对照组,差异有统计学意义(P<0.01)。血浆FIB在Ⅲ+Ⅳ期、T4分期、有淋巴结转移及卡氏评分<80分组要高于相应比较组,差异有统计学差异(P<0.05),而不同分化程度组间差异无统计学意义(P>0.05)。D-二聚体在低分化组、Ⅲ+Ⅳ期、T4分期及有淋巴结转移者要高于相应比较组,差异有统计学意义(P<0.05),而不同卡氏评分组间差异无统计学意义(P>0.05)。结论胃癌患者治疗前血浆D-二聚体、FIB水平如同肿瘤标记物一样可作为诊断的参考指标,两者不仅提示机体高凝状态,并且可作为判断预后的指标。更多还原

【Abstract】 Objective To analyze the relationship between plasma fibrinogen,d-dimer and the clinicopathologic features of gastric cancer. Methods The gastric cancer group was divided into five groups according to the degree of differentiation,pTNM stage,depth of infiltration,lymph node metastasis and physical status(karnofsky performance status,KPS). Plasma FIB and d-dimer levels were measured in the gastric cancer group and the control group, and the differences among different groups were analyzed. Results Plasma FIB and d-dimer in the gastric cancer group were significantly higher than those in the control group(P<0.05). Plasma FIB in stage Ⅲ+Ⅳ,T4 staging, lymph node metastasis and KPS< 80 group is higher than the corresponding comparison group, the difference was statistically difference(P<0.05). There was no significant difference between the groups with different degrees of differentiation(P>0.05). D-dimer in low differentiation,stage Ⅲ+Ⅳ,T4 staging and lymph node metastasis is higher than the corresponding comparison group,the difference was statistically difference(P<0.05). There was no significant difference between the groups with different KPS(P>0.05). Conclusion The plasma FIB and d-dimer level of patients with gastric cancer before treatment can be used as the reference indicators for diagnosis as tumor markers.Both of them not only indicate the hypercoagulable state of the body,but also can be used as prognostic indicators.更多还原