【摘要】 目的探讨血清视黄醇结合蛋白4(RBP-4)与妊娠肥胖、妊娠糖尿病的关系。方法选用2015-01至2016-12住院的32例BMI> 28 kg/m2的妊娠糖尿病(GDM)孕妇(肥胖型GDM组),30例BMI 18. 5～23. 9 kg/m2(单纯型GDM组),29例BMI> 28 kg/m2(妊娠肥胖组),27例BMI18. 5～23. 9 kg/m2的健康孕妇(健康对照组),采用酶联免疫吸附法(ELISA)检测4组孕妇血清RBP-4水平、脂联素(APN)水平;同时测定所有受试者的糖、脂生化指标,并计算胰岛素抵抗指数(HOMAIR)。结果 (1)肥胖型GDM组孕妇血清RBP-4明显高于其他3组孕妇(P <0. 05),妊娠肥胖组孕妇血清RBP-4高于单纯型GDM组及健康对照组(P <0. 05);(2)血清RBP-4与孕前BMI、FINS、TG、HOMA-IR呈正相关,与APN呈负相关(r分别为0. 562,0. 409,0. 484,0. 618,-0. 412,P均<0. 05)。结论 RBP-4水平在妊娠肥胖组及肥胖型GDM组均高于健康对照组,其中肥胖型GDM组孕妇血清升高明显,可见血清RBP-4水平与妊娠肥胖、妊娠糖尿病均有密切联系,特别是对肥胖型GDM患者易生产巨大儿起到非常关键的作用。更多还原

【Abstract】 Objective To investigate the change of serum retinol binding protein 4( RBP-4) levels in obese pregnant women and pregnant women with GDM. Methods Serum RBP-4 and APN levels were detected by Enzyme-Linked Immnno Sorbent Assay( ELISA) in 32 cases of GDM with obesity( BMI > 28 kg/m2,Group A),30 cases of GDM with normal weight( BMI 18. 5-23. 9 kg/m2,Group B),29 cases of obese pregnant women without pregnancy complications( BMI > 28 kg/m2,Group C) and 27 cases of normal-weight pregnant women( BMI 18. 5-23. 9 kg/m2,Group D). Meanwhile,FPG and TG were measured. Insulin resistance was estimated using the homeostatic model assessment insulin resistance( HOMA-IR) index. Results( 1) Serum RBP 4 levels in Group A were significantly higher than those of the other three groups. RBP 4 levels in Group C were higher than those of Group B and Group D( P < 0. 05).( 2) There was a significant positive correlation between RBP4 levels and pregnant BMI,FINS,TG and HOMAIR,but a negative correlation between RBP-4 and APN( r value was 0. 562,0. 409,0. 584,0. 618 and-0. 412 respectively,P <0. 05). Conclusions Serum RBP-4 levels in Groups A,B and C were significantly higher than those of Group D. Serum RBP-4 levels are significantly elevated in obese women,and closely related to obesity.更多还原