【摘要】 叶下珠具有抗乙肝病毒的作用,常用来辅助治疗慢性肝炎。利用分子对接技术,研究叶下珠组分与包膜蛋白preS1、核衣壳蛋白preC以及X蛋白HBx靶点的结合情况。研究结果表明,叶下珠中能够较好地抑制乙肝病毒的成分是Phyllanthusiin、Gallic acid-3-O-(6’-O-galloyl)-glucoside和Phyllanthusiin D。在这三个靶点中,叶下珠主要通过抑制核衣壳蛋白preC起到抑制乙肝病毒的作用。更多还原

【Abstract】 Phyllanthus urinaria L.has anti-HBV effect and is often used to assist in the treatment of chronic hepatitis.In this study,the molecular docking technique is used to study the binding of the Phyllanthus urinaria L.components to the surface protein preS1,core protein preC and X protein HBx.The results show that the components that can effectively inhibit hepatitis B virus in Phyllanthus urinaria L.are Phyllanthusiin,Gallic acid-3-O-(6’-O-galloyl)-glucoside and Phyllanthusiin D.Among these three targets,the Phyllanthus urinaria L.mainly inhibit the hepatitis B virus by inhibiting the core protein preC.更多还原