【摘要】 胃黏膜肠上皮化生(intestinal metaplasia,IM)是胃癌常见的癌前病变,其特征是杯状细胞的出现。IM是多因素共同作用的结果,其发生与年龄、饮食习惯、幽门螺杆菌(Helicobacter pylori,H.pylori)感染、胆汁酸反流、维生素D缺乏、胃癌家族史等因素有关。IM与胃癌的关系已较明确,大量研究证实IM使胃癌发生的风险明显增加,组织分型和病变程度不同,胃癌风险也有较大差异。IM的诊治对胃癌三级预防具有重大意义。随着新型内镜技术的发展,IM的检出率明显增加,但各种新型内镜对于IM的诊断作用尚存在差异,内镜监测策略的完善及个体化防治等仍需多中心、大型的临床研究进一步探索。本文就IM的危险因素、与胃癌相关性、诊断及治疗作一概述,旨在提高临床医师对IM的认识,为胃癌早期监测与预防提供依据。更多还原

【Abstract】 Gastric mucosal intestinal metaplasia(IM) is a common precancerous lesion of gastric cancer, characterized by the appearance of goblet cells. IM is the result of multiple factors, which is related to age, eating habits, Helicobacter pylori(H.pylori) infection, bile acid reflux, vitamin D deficiency, family history of gastric cancer and other factors. The relationship between IM and gastric cancer has been relatively clear. A large number of studies have confirmed that IM significantly increases the risk of gastric cancer, tissue classification and degree of lesion classification are different, and the risk of gastric cancer is also quite different. The diagnosis and treatment of IM are of great significance for the third-level prevention of gastric cancer. With the development of new endoscopic techniques, the detection rate of IM is significantly increased, however, various new endoscopy technologies have different diagnostic effects on IM. The improvement of endoscopic monitoring strategy and individualized prevention and treatment still require further exploration of multi-center and large-scale clinical research. This article reviewed the risk factors of IM, correlation with gastric cancer, diagnosis and treatment, aiming to improve clinicians’ understanding of IM and provide evidence for early monitoring and prevention of gastric cancer.更多还原