【摘要】 挤出沉积快速成型技术具有极高的材料适用性和柔性,因此其在成形方面显示出优势。为了研究骨组织工程支架的孔结构,研究制备了符合浆料要求的微纳米β-磷酸三钙(β-TCP)粉体和具有不同孔径的均孔支架。根据该技术对浆料的要求,研究制备了具有良好分散性、稳定性的β-TCP粉体和浆料。随着聚乙二醇(PEG20000)量的增加,所得粉体纯度更高、结晶更完整、分散性更优;当pH=9.5,分散剂聚丙烯酸铵(PAA-NH4)含量为1%(与粉体质量相比)时,粉体在浆料中能够获得良好的分散稳定性。结合烧结工艺,通过挤出沉积成形技术制备了β-TCP支架。调整工艺参数,制备出具有均匀可控结构、良好联通性的支架,孔径范围在200～800μm之间。更多还原

【Abstract】 The technology based extrusion and deposition of the technology,because of its high adaptability and flexibility, shows the advantages on forming. In order to study the structure of the scaffold for bone tissue engineering, β-thricalcium phosphate(β-TCP)powder and scaffold with different sizes of pore are prepared. According to the requirements of slurry, β-TCP powder and slurry with high concentration, good dispersibility and stability were prepared. With the increase of PEG20000, β-TCP were prepared with higher purity, crystalline state, and better dispersion; and when pH=9.5, the dispersing agent PAA-NH4 is 1%(compared with the powder weight), there is good dispersion stability in slurry for β-TCP powder. Combining with sintering process, the scaffolds were formed by the technology. With the adjustment of the process parameters, prepare the uniform scaffolds with the controllable structure and good connectivity. The range of the pore size is 200-800 μm.更多还原