【摘要】 目的:通过观察黄连对正常大鼠大肠和小肠形态的改变,阐明黄连降脂、止泻的作用机制。方法:正常雄性SD大鼠随机分为空白对照组和黄连组,分别用等剂量生理盐水和黄连水煎剂灌胃4 d后,处死大鼠,AB-PAS染色观察回肠、结肠部形态变化。结果:黄连组与空白组相比,回肠肠绒毛变短小,肠壁变薄,上皮层覆盖的黏液增多;结肠内绒毛变长,肠壁增厚,上皮层覆盖的黏液减少。结论:肠形态结构的变化为黄连降脂、止泻作用提供实验室依据。更多还原

【Abstract】 Objective: To observe the effects of Rhizoma Coptidis( RC) on small intestine and colon morphology in normal rats,in order to expound its lipid-lowering and anti-diarrhea mechanisms. Methods: Ten male Sprague-Dawley rats were randomly divided into control group and the RC group,and were given by gavage twice a day with saline or water decoction of RC respectively for 4 days. Then,all rats were sacrificed,and the pathological changes of ileum and colon tissues were observed under light microscope after AB/PAS staining.Results: Compared with the control group,the villi of ileum were shorter,the wall of ileum were thinner and mucous layer were thicker in RC group. While the villi of colon were longer,the wall of colon were thicker and mucous layer were thinner in RC group. Conclusion: The mechanisms on lipid-lowering and anti-diarrhea of RC were associated with its effects on small intestine and colon morphology.更多还原