【摘要】 目的:探讨血浆corin、脑啡肽酶(NEP)、B型利钠肽(BNP)在慢性心功能衰竭患者病情评估中的临床价值及其与左心室收缩功能的相关性。方法:选取2016年1月-2018年1月在我院心内科就诊的患者为研究对象,根据患者心衰评分及EF值分组:无心衰正常EF组(nEF对照组),无心衰收缩功能减低组(rEF+nHF,rEF≤50%),和收缩功能减低心衰组(rEF+dHF,rEF≤50%),每组32例。采用酶联免疫吸附法检测各组血浆corin、NEP、BNP浓度,并比较分析其变化情况。结果:一般临床资料组间比较无差别(P>0.05)。EF减低组血清corin浓度均明显低于nEF对照组(P <0.05),而血清NEP、BNP浓度均明显高于nEF对照组(P <0.05)。血浆corin和NEP浓度呈负相关关系。多元线性回归分析血浆corin水平是LVEF的独立风险因素。结论:血浆corin、NEP、BNP水平与心衰患者心脏收缩功能变化有关,监测血浆corin水平有望为心衰的治疗提供新的思路。更多还原

【Abstract】 Objective:The aim of the study was to evaluate the clinical value of serum corin, NEP and BNP in patients with chronic heart failure and its correlation with left ventricle systolic function. Methods:Patients admitted to the department of cardiology were eligible for the study from January 2016 to January 2018. Patients were divided into 3 groups according to the Framingham heart failure criteria and ejection fraction(EF), namely, no HF and normal EF(nEF control group), no HF and systolic dysfunction(rEF≤50%)(rEF+nHF group), and HF with systolic dysfunction(rEF≤50%)(rEF+dHF group), 32 patients in each group. The serum corin, NEP and BNP levels were measured by ELISA, and their difference among the groups were analyzed. Results:There was no statistically significant difference in the general characteristics among the groups(P >0.05). Serum corin level in rEF group was significantly lower than that of nEF control group(P <0.05),while serum NEP and BNP levels were significantly higher than those of nEF control group(P <0.05). There was a negative correlation between serum corin and NEP levels. Multivariate linear regression analysis showed that plasma corin level was an independent factor of LVEF. Conclusion:Serum corin, NEP and BNP levels were related to cardiac systolic function in patients with heart failure. Measuring serum corin level may provide a new idea for the treatment of heart failure.更多还原