【摘要】 虽然胰腺癌手术方式和放、化疗方案有了长足发展,但胰腺癌仍然是致死率最高的恶性肿瘤,5年总生存率仅约为4%。研究表明,胰腺癌局部复发进展是致死率高的重要原因,局部切除后失败率仍高达50%～80%。所以,如何提高胰腺癌局部控制率一直是关注的热点。由于胰腺临近的器官、组织(如骨髓、脊髓、肾脏、肝脏、肠等)较多从而限制外照射(EBRT)剂量。提高局部控制率和减少治疗毒副反应是未来治疗的趋势。术中放疗有剂量学和直视下治疗的优势,已越来越多的应用于胰腺癌的治疗,成为综合治疗中的重要部分。本文整理、总结了近年来有关胰腺癌术中放疗临床研究结果,以期为广大临床医生提供参考。更多还原

【Abstract】 Although surgery,radiotherapy and chemotherapy have made great progress,pancreatic cancer is still the most fatal malignant tumor,with a 5-year overall survival rate of only about 4%.Many studies have demonstrated that the local recurrence of pancreatic cancer is an important cause of high mortality,and the failure rate after local excision is still as high as 50～80%.Therefore,how to improve the local control rate of pancreatic cancer has been a hot spot of concern.Due to the adjacent organs and tissues(such as bone marrow,spinal cord,kidney,liver,intestine,etc.),the dose of external irradiation(EBRT)is limited.Increasing local control rates and reducing treatment side effects are trends in future treatments.Intraoperative radiotherapy has the advantages of dosimetry and direct vision treatment to be increasingly used in the treatment of pancreatic cancer,becoming an important part of comprehensive treatment.This article summarizes the clinical research results of intraoperative radiotherapy for pancreatic cancer in recent years,in order to provide the reference for clinicians.更多还原