【摘要】 目的制备和厚朴酚(Honokiol,HNK)固体分散体(solid dispersion,SD),以期提高HNK的体外溶出度。方法以溶出度为指标,采用溶剂蒸发法制备HNK-SD,正交实验设计优选最佳制备工艺,利用扫描电子显微镜(SEM)、差示扫描量热分析(DSC)、粉末X衍射(XRD)和傅里叶变换红外光谱(FT-IR)对HNK-SD进行表征。结果以PVP K30为载体制备的固体分散体溶出率优于其他载体,以HNK∶载体为体积比1∶5,PVPK30∶Tween80体积比9∶1作为联合载体,超声时间10 min,水浴温度50℃时制备的固体分散体最佳;药物在固体分散体中以无定形形式存在,可能与载体之间以氢键连接。结论溶剂蒸发法制备HNK-SD工艺简单可行,HNK-SD能显著提高HNK的体外溶出度。更多还原

【Abstract】 Objective To prepare the solid dispersion of Honokiol（HNK） for improving the dissolution rate of HNK in vitro.Methods Solvent method was used to prepare HNK-SD,and orthogonal experimental was designed to optimize the preparation technology using in vitro dissolution as index.The structure of HNK-SD was characterized by SEM,DSC,XRD and FT-IR.Results The solid dispersion prepared with PVPK30 as carrier was better to improve HNK’s dissolution than those with others,and when m_HNK∶m_Carrier=1∶5 and PVPK30∶T80=9∶1 as the combined carrier,10 min of ultrasound and the water bath temperature was 50℃,the solid dispersion was best.The drug existed in the amorphous form of solid dispersion,and might be connected with the carrier by hydrogen bonds.Conclusion The preparation of HNK-SD by solvent evaporation is simple and feasible,and HNK-SD can significantly improve the dissolution of HNK in vitro.更多还原