【摘要】 维生素K1是血液凝固的重要因素。近20年来发现维生素K2有着与维生素K1不同的健康效应:抗骨质疏松、抗动脉钙化等等。让临床医师有些应接不暇,使他们担忧服用维生素K2补充剂是否会带来干扰凝血机制的问题,是否会引起出血或者形成血栓。为此,我们解读最近发表的《美国药典委员会对MK-7(维生素K2)安全性评价》,对MK-7生理学的介绍:MK-7的代谢、维生素K2依赖性蛋白、MK-7与维生素D和钙的协同健康效应;对MK-7安全性的评价:MK-7的检索文献分析、临床试验的不良反应、服用的不良事件报告、MK-7和抗凝药物之间的相互作用、MK-7食物过敏的安全性和MK-7的安全系数;以及对MK-7膳食补充剂的管理。供临床医师参考。更多还原

【Abstract】 Vitamin K1 is an important factor in blood coagulation.In the past 20 years,vitamin K2 has been found to have different health effects from vitamin K1,such as anti-osteoporosis,anti-artery calcification,and so on.However,some clinicians still worry whether taking vitamin K2 supplements may cause interference with the clotting mechanism that can result in bleeding or thrombus formation.Therefore,we interpret the newly published"Safety evaluation of menaquinone-7,a form of vitamin K by the US Pharmacopeial Convention".We introduce the physiology of MK-7 including vitamin K2 metabolism,vitamin K2-dependent proteins,synergetic health effects of vitamin D and calcium with MK-7.The safety evaluation of MK-7 from the US Pharmacopeial Convention covers the analysis of the MK-7 literatures,adverse reactions in the clinical trials,the reports of adverse events from taking MK-7,interactions between MK-7 and anticoagulant drugs,MK-7 food allergy and the safety margin of MK-7,and the management of MK-7 dietary supplements for reference to the clinicians as well.更多还原