【摘要】 目的:总结头颈部肌纤维瘤的临床病理特点。方法:纳入22例头颈部肌纤维瘤患者的临床资料,并对其组织切片进行HE和免疫组化染色分析。结果:22例头颈部肌纤维瘤病例男女各11例,中位年龄6.5岁,多见于下颌骨(7例)、下颌牙龈(5例)。影像学表现为近肌组织密度的占位性病变。光镜下可见双相表现,免疫组化:Vimentin(+),SMA(+),Calponin(+),Desmin(-),Caldesmon(-)。平均随访时间21个月,3例术后复发,局部切除(n=14)和扩大切除(n=8)与肿瘤复发率无显著相关性(P=0.15)。结论:头颈部肌纤维瘤好发于儿童,局部病灶切除或颌骨病灶刮治手术预后好。免疫组化染色对肌纤维瘤病理诊断意义重大。更多还原

【Abstract】 Objective: To study the clinical and histopathologic features of myofibroma in head and neck region. Methods: 22 cases of myofibroma in head and neck region were retrospectively analyzed by morphological observation and immunohistochemistry. Results: There were 11 males and 11 females of the 22 cases with a median age of 6.5 years. The lesion in mandible and gingiva was in 7 and 5 cases respectively. The imaging findings showed masses of similar density with muscle. Histopathological examination revealed a biphasic pattern. The immunohistochemical tests showed vimentin(+), SMA(+), calponin(+), desmin(-), caldesmon(-). Tumor recurrence was found in 3 patients after an average 21-month follow-up. No significant difference(P=0.15) between the conservative operation group(n=14) and the radical operation group(n=8). Conclusion: Myofibroma mostly develops in children in head and neck region. Local and complete excision is recommended for favorable outcomes. Immunohistochemical stain plays an important role in pathological diagnosis.更多还原