【摘要】 目的 探讨鼻咽癌（NPC）DCE-MRI定量参数直方图分析与临床分期的相关性。方法 对70例经病理证实的NPC患者行MRI检查并分期,用全容积ROI设置法对NPC癌灶进行测量,对得到的DCE-MRI定量参数行直方图分析。采用Spearman相关分析评价DCE-MRI定量参数直方图分析结果与NPC临床分期的相关性。结果 全容积直方图分析的转运常数(K^trans)值的平均数、10%位数、75%位数、90%位数、速率常数(K_ep)值的平均数、10%位数、峰度及血管外细胞外间隙体积百分比（Ve）值的平均数、90%位数、偏度与T分期相关（P均<0.05）,其中K^trans值75%位数的Spearman相关系数最大。K^trans值的平均数及V_e值的平均数、90%位数与N分期相关（P均<0.05）,其中V_e值90%位数的Spearman相关系数最大。K_ep值的峰度及V_e值的平均数与M分期相关（P均<0.05）。全容积直方图分析结果显示K_ep各参数值与N分期无相关性,K^ttans各参数值与M分期无相关性。K^trans值的平均数、10%位数、75%位数、90%位数、K_ep值的10%位数、75%位数、峰度及Ve值的平均数、75%位数、90%位数与临床总分期相关（P均<0.05）,其中Ve值90%位数的Spearman相关系数最大。结论 DCE-MRI定量参数全容积直方图分析结果显示多个参数与NPC临床分期存在相关性;可以多参数、无创地反映NPC的侵袭性、疾病进展,对NPC的临床分期具有一定的指导作用,为治疗方案的制订提供潜在依据。更多还原

【Abstract】 Objective To investigate the relationship between histogram analysis of DCE-MRI quantitative parameters and clinical stage of nasopharyngeal carcinoma（NPC）.Methods 70 patients with NPC confirmed by pathology underwent MRI examination and staging.NPC tumors were measured by full-volume ROI setting method,and the obtained DCE-MRI quantitative parameters were analyzed by histogram.Spearman correlation coefficients were obtained to evaluate the potential correlation between the DCE-MRI histogram quantitative parameters and NPC clinical stages.Results The histogram-based Ktrans（mean,10 th,75 th,90 th）,Kep（mean,10 th,kurtosis）,and Ve（mean,90 th,skewness） had correlation with T stage（P <0.05,respectively）.The histogram-based K^trans（mean） and Ve（mean,90 th）showed correlation with N stage（P<0.05,respectively）.The histogram-based Kep（kurtosis） and Ve（mean） had correlation with M stage（P<0.05,respectively）.The his to gram-based Kep had no correlation with N stage,and K^trans had no correlation with M stage.The histogram-based Ktrans（mean,10 th,75 th,90 th）,Kep（10 th,75 th,kurtosis） and V_e（mean,75 th,90 th） had correlation with overall stage（P<0.05,respectively）.Conclusion The histogram analysis of DCE-MRI quantitative parameters showed that the multiple parameters associated with NPC overall stages.DCE-MRI quantitative parameters non-invasively reflect the aggressiveness and progression of NPC.The histogram analysis of DCE-MRI quantitative parameters may play a role in clinical stage of NPC.更多还原