【摘要】 DNA光修复酶在蓝光驱动下,利用黄素腺嘌呤二核苷酸(FAD)分子的黄素酶作为催化辅助因子,来修复紫外线诱导的环丁烷嘧啶二聚体(CPD)和嘧啶(6-4)嘧啶酮的DNA损伤产物。通过无根发育树,综述了DNA光修复酶/隐花色素家族的分类;详细地阐述两种DNA光修复酶的结构、光损伤后产生的嘧啶二聚体的结构及光修复过程;最后回顾了DNA光修复酶的研究现状并展望该领域的发展前景。更多还原

【Abstract】 Under blue light, DNA photolyase can repair UV-induced DNA damage products of cyclobutane pyrimidine dimer(CPD) and pyrimidine(6-4) pyrimidinone, using flavin adenine dinucleotide(FAD). Here we review the classification of the photorepairase/cryptochrome family,through the rootless development tree. We elaborate on the structure of the two DNA photolyases,the structure of the pyrimidine dimer produced after photodamage,and the photoremediation process,and the research status of photoremediation enzymes. We also propose a development prospect in this field.更多还原