【摘要】 建立一种饮用水中痕量双酚A和双酚S的固相萃取-超高效液相色谱-串联质谱检测方法。水样中双酚A和双酚S经HLB固相萃取柱富集,甲醇洗脱并浓缩,再以1 mmol/L氟化铵-乙腈为流动相,经C18色谱柱分离,采用电喷雾离子源、质谱多反应监测模式分析。该方法对水样体积为500 mL时双酚A和双酚S检出限分别可达到1.0 ng/L和0.2 ng/L,在低、中、高3个加标水平下两者的平均回收率分别为88.3%～114.8%和83.7%～98.2%,相对标准偏差分别为10.0%～16.2%和5.9%～12.3%。该方法灵敏度高、定性准确、操作简单高效,适用于饮用水中双酚A和双酚S的定性定量分析。更多还原

【Abstract】 An analytical method was established for the determination of bisphenol A(BPA) and bisphenol S(BPS) in drinking water by solid-phase extraction and ultra performance liquid chromatography-tandem mass spectrometry(SPEUPLC-MS/MS). BPA and BPS from samples were enriched by an Oasis HLB SPE cartridge, eluted with methanol and concentrated with nitrogen. The analytes were separated on an C18 column with 1 mmol/L NH4 F aqueous-acetonitrile as the mobile phase, and then analyzed by UPLC-MS/MS using multiple reaction monitoring(MRM) under the negative-ion mode. The limits of detection(LODs) of the method for BPA and BPS were 1.0 and 0.2 ng/L, respectively. The mean recoveries at three spiked levels of BPA ranged from 88.3% to 114.8%, with relative standard deviations(RSDs) of 10.0%–16.2%. The recoveries of BPS were 83.7%–98.2%, with RSDs of 5.9%–12.3%. The method was proved to be sensitive, accurate and efficient, and it was suitable for qualitative and quantitative analysis of BPA and BPS in drinking water.更多还原