【摘要】 以蛋黄卵磷脂为模板调控CaCO₃生物矿化,制备结构稳定、尺寸均一的CaCO₃微球,以该材料为载体,制备姜黄素碳酸钙微球,并研究该微球对姜黄素溶出速率及溶出度的影响。采用溶剂法制备微球,利用扫描电镜、透射电镜、差示量热扫描分析等多种表征手段对CaCO₃微球及姜黄素碳酸钙微球的结构特征进行分析研究,并考察其体外释药性能。药物与CaCO₃微球比例1︰4时所制备的姜黄素碳酸钙微球,能显著提高姜黄素的溶出速率和溶出度。蛋黄卵磷脂调控后的CaCO₃微球可为提高水难溶性姜黄素的生物利用度提供新方法。更多还原

【Abstract】 Egg yolk lecithin was used as the template to regulate the biomineralization of CaCO₃, to prepare CaCO₃ microspheres with stable structures and uniform sizes. Taking CaCO₃ as carrier, prepare calcium carbonate microspheres of curumin for study on its effect on the dissolution rate and solubility of curumin. Calcium carbonate microspheres of curumin were obtained using the solvent method. Different characterization methods, such as transmission electron microscope, scanning electron microscope, and differential scanning calorimetry, are adopted to analyze and study architectural features of CaCO₃ microspheres and calcium carbonate microspheres of curumin, as well as the drug-release performance. The calcium carbonate microspheres of curumin, based on the drug to CaCO₃ microspheres of 1︰4, significantly enhance the dissolution rate and dissolution degree of curumin. CaCO₃ microspheres regulated by egg yolk lecithin, could improve the cumulative dissolutio rate and solubility of curumin, which provided an effective method for solving the water non-solubility of curumin.更多还原