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哺乳动物精卵融合必需蛋白质IZUMO1-JUNO/CD9的研究进展
Progress of Essential Proteins IZUMO1-JUNO/CD9 Involved in Mammalian Sperm-egg Fusion
【摘要】 精卵融合是受精过程中最为重要的步骤。目前公认IZUMO1、JUNO和CD9 (cluster of differentiation antigen 9)为精卵融合的必需蛋白质,其中IZUMO1与JUNO在精卵识别时会形成复合体。有研究表明IZUMO1、JUNO和CD9主要参与精卵融合最初的黏附过程,且它们之间是相互关联发挥作用的。近年来由于X射线晶体学相关技术的发展, IZUMO1-JUNO晶体结构基本被阐明,然而精卵融合的具体分子机制仍未被完全揭示。所以,对哺乳动物精卵融合必需蛋白质IZUMO1-JUNO/CD9的结构、功能和分子机制进行阐述是十分必要的。
【Abstract】 Sperm-egg fusion is the most important step in the process of fertilization. IZUMO1, JUNO and cluster of differentiation antigen 9(CD9) are currently recognized as essential proteins for sperm-egg fusion.IZUMO1 and JUNO form a complex when the sperm is recognized. Studies have shown that IZUMO1, JUNO and CD9 are mainly involved in the initial adhesion process of sperm-egg fusion, and they are interrelated.In recent years, the crystal structure of IZUMO1-JUNO has been basically elucidated with the development of X-ray crystallography. However, the specific molecular mechanism of sperm-egg fusion has not been fully revealed. Therefore, it is necessary that the structure, function and molecular mechanism of the essential pro-teins IZUMO1-JUNO/CD9 involved in the mammalian sperm-egg fusion should be elaborated.
- 【文献出处】 生命科学研究 ,Life Science Research , 编辑部邮箱 ,2019年03期
- 【分类号】Q492.6
- 【被引频次】1
- 【下载频次】256