【摘要】 目的利用数据挖掘及文献研究,汇总分析溃疡性结肠炎(UC)中医药内服及灌肠治疗的方药规律。方法检索中国知网学术期刊全文数据库、万方数据库、维普数据库收录的近10年公开发表的中医药治疗UC的临床研究文献,建立文献研究数据库,对涉及的方剂、中药的功效类别、频次频率等进行统计,再对核心用药进行关联规则和网络图的数据挖掘分析。结果①最终纳入相关文献339篇,涉及内服方剂50个,以乌梅丸使用最多,关联规则亦显示"乌梅-附子-黄连"强关联;常用药物167味,其中补虚药占31.11%、清热药占20.15%,使用频率在10%以上者有甘草、黄连、白术、白芍、党参、当归、木香、茯苓、黄芩、黄芪、白头翁、陈皮、乌梅等26味;关联规则显示健脾益气类中药强关联。②灌肠方剂16个,以白头翁汤使用最多,关联规则亦显示"白头翁-秦皮-黄柏-黄连"强关联;常用药物123味,其中清热药占39.17%、止血药占17.72%,使用频率在10%以上的中药有黄连、白及、黄柏、地榆、白头翁、黄芩、苦参、败酱草等17味;网络图显示"白头翁-黄连-黄柏-白及-地榆"强关联;中成药5种,锡类散使用最多。③黄连在内服和外用中药关联规则和网络图中均表现出与其他药物的强关联。结论 UC的中医药内服治疗重在健脾益气扶正、清热燥湿祛邪,以乌梅丸最为常用;局部灌肠治疗以清热解毒燥湿、收敛止血、化腐生肌为主,以白头翁汤及锡类散最为常用;综合内服和灌肠中药,最常用的药物是黄连。更多还原

【Abstract】 Objective To summarize and analyze the patterns of prescriptions and medicines for oral administration and enema in the treatment of ulcerative colitis(UC) with traditional Chinese medicine(TCM) by data mining and literature research. Methods Clinical research literatures on the treatment of UC with Chinese medicine published in the last 10 years were retrieved in databases including CNKI, Wanfang Data and VIP. A literature research database was established, a statistical analysis was performed on the effect category and frequency of the herbs and prescriptions discussed in the literatures,and data mining analysis of association rules and network diagram was carried out on core prescriptions and herbs. Results(1) A total of 339 relevant articles were included: 50 prescriptions were for oral administration,the most commonly used was Wumei Pill,and the association rules also showed a strong association of"Wumei-Fuzi-Huanglian"; 167 Chinese herbs were used commonly,31.11% of them were tonifying herbs and 20.15% were heat-clearing herbs; 26 Chinese herbs were used with a frequency over 10%,such as Gancao,Huanglian,Baizhu,Baishao,Dangshen,Danggui,Muxiang,Fuling,Huangqin,Huangqi,Baitouweng,Chenpi,Wumei,etc.,and the association rules showed a strong association of herbs invigorating the spleen and tonifying qi.(2)16 prescriptions were used for enema and the most commonly used was Baitouweng Decoction,and the association rules also showed a strong association of "BaitouwengQinpi-Huangbai-Huanglian"; 123 Chinese herbs were used commonly,39.17% of them were heat-clearing herbs,17.72% were hemostatic herbs,and17 Chinese herbs were used with a frequency over 10%,such as Huanglian,Baiji,Huangbai,Diyu,Baitouweng,Huangqin,Kushen,Baijiangcao,etc. The network diagram showed a strong association of"Baitouweng-Huanglian-Huangbai-Baiji-Diyu". 5 Chinese patent medicines were used,and Xilei Powder was the most commonly used.(3)Huanglian had a strong association with the other drugs in association rules and network diagram of both oral administration and enema. Conclusion Oral administration of Chinese medicines to treat UC is mainly focused on reinforcement of healthy qi by invigorating spleen and replenishing qi,and elimination of pathogenic factors by clearing heat and drying dampness,with the most commonly used prescription being Wumei Pill; in treatment by enema,it is mainly focused on clearing heat,removing toxins,drying dampness,stanching bleeding,resolving putridity and promoting granulation,with the most commonly used prescriptions being Baitouweng Decoction and Xilei Powder. Overall,the most commonly used herb is Huanglian both for oral administration and enema.更多还原