【摘要】 目的探讨苍南县革兰阳性菌分布情况,并分析其耐药性,为临床积极预防与控制医院感染提供参考依据。方法对2016年1月—2017年12月苍南县第二人民医院分离的517株革兰阳性菌、苍南县第三人民医院分离的463株革兰阳性菌和苍南县人民医院分离的869株革兰阳性菌进行菌种鉴定和体外药物敏感性试验。结果 1 849株革兰阳性菌中,金黄色葡萄球菌718株(38.83%)、表皮葡萄球菌431株(23.31%)、溶血葡萄球菌240株(12.98%)、肺炎链球菌60株(3.24%)、无乳链球菌100株(5.41%)、粪肠球菌200株(10.82%)、屎肠球菌100株(5.41%)。718株金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)为481株(66.99%)。所有葡萄球菌均对替加环素和利奈唑胺敏感。粪肠球菌对万古霉素和替加环素均敏感(100.0%),对利奈唑胺的耐药率为2.0%。屎肠球菌对利奈唑胺及替加环素的耐药率均为1.0%。肺炎链球菌对替加环素和万古霉素均敏感(100.0%)。结论苍南县革兰阳性细菌中主要以金黄色葡萄球菌为主,其次为表皮葡萄球菌;且MRSA高达66.99%,肠球菌也存在不同程度的耐药性。更多还原

【Abstract】 Objective To investigate the distribution and drug resistance of Gram-positive bacteria in Cangnan County,and to provide a reference for the clinical prevention and control of nosocomial infection. Methods A total of 517 isolates of Gram-positive bacteria from Cangnan County Second People’s Hospital,463 isolates of Grampositive bacteria from Cangnan County Third People’s Hospital and 869 isolates of Gram-positive bacteria from Cangnan County People’s Hospital were collected from January 2016 to December 2017. Bacterial identi?cation and drug susceptibility test in vitro were performed. Results Among the 1 849 isolates of Gram-positive bacteria,there were 718 isolates of Staphylococcus aureus(38.83%),431 isolates of Staphylococcus epidermidis(23.31%),240 isolates of Staphylococcus haemolyticus(12.98%),60 isolates of Streptococcus pneumoniae(3.24%),100 isolates of Streptococcus agalactiae(5.41%),200 isolates of Enterococcus faecalis(10.82% and 100 isolates of Enterococcus faecium(5.41%). Among the 718 isolates of Staphylococcus aureus,481 isolates(66.99%) were methicillin-resistant Staphylococcus aureus(MRSA). All isolates of Staphylococcus were sensitive to tigecycline and linezolid. The isolates of Enterococcus faecalis were sensitive to vancomycin and tigecycline(100.0%),and they had different degrees of resistance to linezolid(2.0%). The isolates of Enterococcus faecium had different degrees of resistance to linezolid(1.0%) and tigecycline(1.0%). The isolates of Streptococcus pneumoniae were sensitive to tigecycline and vancomycin(100.0%). Conclusions Among the isolates of Gram-positive bacteria in Cangnan County,Staphylococcus aureus is the main one,followed by Staphylococcus epidermidis,and MRSA is as high as 66.99%. Enterococcus has different degrees of drug resistance.更多还原