【摘要】 目的通过相关生物力学方面检测,评价利塞膦酸钠对于大鼠骨质疏松性骨折愈合的影响。方法本实验采用健康6月龄SD雌性大鼠90只,随机分为A、B、C3组:正常对照组(A组),去卵巢模型+股骨干骨折模型+利塞膦酸钠灌胃治疗组(B组)和去卵巢模型+股骨干骨折模型+生理盐水灌胃组(C组)。各组大鼠骨折建模前随机抽取10只行断尾抽血,在处死大鼠后取出右侧股骨干内固定物,并制作病理,后检测右侧股骨干骨折愈合处骨密度(bone density,BMD)数值,检测右侧股骨的最大载荷、最大载荷恢复率。骨折建模后第3、6周,再次对各组大鼠进行检测。结果在各组大鼠骨折建模过程BMD值组间、组内对比情况中,建模前各组大鼠组间对比,差异无统计学意义(P>0.05),余各组间、组内对比,差异有统计学意义(P<0.05);在各组大鼠骨质疏松性骨折建模前后生物力学性能组间、组内对比情况,差异有统计学意义(P<0.05),除了在最大载荷恢复率中,B、C组间对比,差异无统计学意义(P>0.05);在最大载荷中,C组组内对比差异无统计学意义(P>0.05)。结论利塞膦酸钠短期内应用可促进骨质疏松性骨折的愈合。更多还原

【Abstract】 Objective To evaluate the effect of risedronate on the healing of osteoporotic fracture in rats by relevant biomechanics.Methods Ninety healthy female SD rats aged 6 months were randomly divided into A,B,and C3 groups:normal control group(group A),ovariectomized model+femoral shaft fracture model+ risedronate sodium.Treatment group(group B)and ovariectomized model+femoral shaft fracture model+saline gavage group(group C).Before the fracture modeling of each group,10 paw withdrawals were randomly selected,and the BMD value of the right femur fracture healing was detected.After the sacrificed rats,the right femoral stem was taken to detect the maximum load at the new epiphysis,the maximum load recovery rate.At the 3 rd and 6 th week after fracture modeling,rats in each group were tested again.Results In the modeling of fractures of rats in each group,the BMD value group and the intragroup comparison,before the modeling group,the P>0.05,the results were not statistically significant.In the comparison of mean values between groups and groups,the results were statistically significant(P<0.05).In the comparison between the biomechanical properties of the groups before and after the modeling of osteoporotic fractures in each group,the results were statistically significant(P<0.05),except in the maximum load recovery rate.In the comparison between groups B and C,the results were not statistically significant.In the maximum load,the results were not statistically significantin Group C.Conclusion The short-term application of risedronate sodium can promote the healing of osteoporotic fractures.更多还原