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基于不平衡分类的原发性肝癌患者无病生存期预测研究

Prediction of disease-free survival in patients with hepatocellular carcinoma based on imbalance classification

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【作者】 杨日东李琳陈秋源华赟鹏周毅

【Author】 YANG Ridong;LI Lin;CHEN Qiuyuan;HUA Yunpeng;Zhou Yi;Zhongshan School of Medicine,Sun Yat-sen University;School of Public Health,Xinjiang Medical University;Department of Hepatobiliary Surgery,The First Affiliated Hospital of Sun Yat-sen University;

【通讯作者】 周毅;

【机构】 中山大学中山医学院新疆医科大学公共卫生学院中山大学附属第一医院肝胆外科

【摘要】 为了预测原发性肝癌患者的术后无病生存期能否达到5年。针对患者临床数据类不平衡的特性,修改传统提升算法中样本权重和基分类器权重的更新方式,并结合决策树,提出一种改进的提升树算法。在患者的临床数据集上,将改进的提升树与传统提升树、结合多种采样技术的决策树作对比。发现改进提升树的F值、G均值和AUC等指标都取得最优值。在所研究的方法中,改进的提升树在原发性肝癌患者的5年无病生存期预测中性能最佳,可为同类研究提供方法学参考。

【Abstract】 To predict whether the disease-free survival time of patients with hepatocellular carcinoma can over 5 years.Aiming at the imbalance of clinical data, we modified the update method of sample weight and base classifier weight in traditional boosting algorithm. Combined with decision tree, an improved boosting tree algorithm was proposed.Compared with the traditional boosting tree and the decision tree combined with multiple sampling techniques on the clinical data sets, the F measure, G mean and AUC of the improved boosting tree were all optimal. Among the methods studied in this paper, the improved boosting tree has a best performance on predicting the 5-year disease-free survival of patients with hepatocellular carcinoma. It can provide a methodological reference for similar research.

【基金】 国家重点研发计划项目(2018YFC0116902,2016YFC0901602);国家自然科学基金资助项目(61876194);NSFC-广东大数据科学中心联合基金资助项目(U1611261);广州市科技计划项目(201604020016)
  • 【文献出处】 生物医学工程研究 ,Journal of Biomedical Engineering Research , 编辑部邮箱 ,2019年01期
  • 【分类号】TP181;R735.7
  • 【被引频次】3
  • 【下载频次】111
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