【摘要】 目的:分析2011～2015年间不同地区医院诊治的软组织肉瘤患者的临床特征分布,为进一步规范化诊疗提供循证医学证据。方法:研究参与单位为北京市、河南省、河北省、湖北省、浙江省、广东省6省市15家二级以上医院,其中三级医院14家,二级甲等综合性医院1家。收集2011年至2015年所在这些医院收治的全部首诊为软组织肉瘤患者的临床信息。设计统一调查表,使用Epidata 3. 0软件进行平行双录入。肿瘤部位、病理组织类型编码规则以国际疾病分类肿瘤学专辑第三版编码(ICD-O-3)为准。年龄为首诊时实足年龄,划分为18个年龄组和4个年龄段。并统计治疗方式信息。结果:2011年至2015年间,15家医院共收集3 712名病例(1 895例男性,1 817例女性)。胃肠道间质瘤是最常见的病理组织类型(534例),占所有病例的14. 39%,其次是未特指的软组织肉瘤(521例),占所有病例的14. 04%。软组织肉瘤可发生于身体任何部位,其中以结缔组织和软组织,如头部、四肢和盆腔等部位的结缔组织和软组织发病最多,共1 130例,占所有病例的30. 44%。女性55～59岁病例占比最高,占13. 54%,男性60～64岁最多,占12. 98%。0～14、15～44岁年龄组最常见的病理类型依次是恶性横纹肌肉瘤、软组织肉瘤(未特指),45岁以及≥60岁年龄组最常见的病理类型均是胃肠道间质性肉瘤。手术是最常见的治疗方式,其次是化疗和放疗。结论:胃肠道间质瘤是软组织肉瘤最常见的病理类型,好发于高年龄组人群。男性发病高峰年龄高于女性。软组织肉瘤的治疗方式以手术为主,各医院治疗方式不同,应进一步制定软组织肉瘤治疗规范。更多还原

【Abstract】 To analyze the clinical characteristics of soft tissue sarcomas( STS) diagnosed from different hospitals between 2011 and 2015 to provide evidence-based information for further standardized diagnosis and treatment of STS. Methods: Data were from 15 hospitals,including 14 tertiary hospitals and 1 level A secondary general hospital,from Beijing,Henan,Hebei,Hubei,Zhejiang,Guangdong provinces. Clinical information of patients who were newly diagnosed was collected from 2011 to 2015. The questionnaire was self-made and data were entered using Epidata 3. 0. Tumor sites,histological types were coded according to International Classification of Diseases for Oncology( third version). Chronological ages at first diagnosis were further classified into 18 age groups and 4 age brackets. Main therapeutics were analyzed. Results: A total of 3,712 patients( 1,895 males and 1,817 females) were enrolled from 15 hospitals. The most common histological subtype of STS was gastrointestinal stromal tumor( 543 cases,14. 39%),followed by sarcomas( not otherwise specified)( 521 cases,14. 04%). STS could occur anywhere in the body. It could be found in connective and soft tissue( 1,130 cases,30.44%) in head,limbs,and pelvic and so on. New cases of STS peaked in females aged 55-59( 13. 54%) and in males aged 60-64( 12. 98%),respectively. The most common histological subtype of STS in 0-to-14-year-olds and 15-to-44-year-olds were rhabdomyoma and sarcoma( not otherwise specified),respectively. Gastrointestinal stromal tumor was the most common histologic subtype of STS in people aged 45-59 and over 60. The most common therapeutic was surgery,followed by chemotherapy and radiotherapy. Conclusion: Gastrointestinal stromal tumor is the most common histological subtype of STS,especially in the elderly. Males have a later peak in age of onset. The most common therapeutic of STS was surgery. Standard should be further developed for the selection of therapeutics.更多还原