【摘要】 目的:观察重剂大黄白术通便方保留灌肠治疗术后早期炎性肠梗阻的临床疗效。方法:将50例术后早期炎性肠梗阻患者按随机数字表法分为对照组26例和治疗组24例。对照组给予胃肠减压、禁食、补液、抗感染等治疗,治疗组在对照组基础上加重剂大黄白术通便方保留灌肠。2组均治疗7天。结果:治愈率治疗组80.8%,对照组45.8%,2组比较,差异有统计学意义(P <0.05)。治疗组肠鸣音恢复时间、排气排便恢复时间及腹痛缓解时间均短于对照组,差异均有统计学意义(P <0.05)。治疗7、14天,2组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)及C-反应蛋白(CRP)水平均较治疗1天时降低(P <0.01);治疗组血清TNF-α、IL-6、IL-8及CRP水平均低于同期对照组(P <0.01)。结论:重剂大黄白术通便方保留灌肠治疗术后早期炎性肠梗阻,能改善患者的临床症状及肠功能,控制炎症反应。更多还原

【Abstract】 Objective:To observe the clinical effect of retention enema with Dahuang Baizhu constipation-relieving heavy prescription for early postoperative inflammatory intestinal obstruction. Methods: Divided 50 cases of patients with early postoperative inflammatory intestinal obstruction randomly into the control group(26 cases) and the treatment group(24 cases).The control group was given treatment such as gastrointestinal decompression,fasting,fluid replacement,and anti-infection,while the treatment group was additionally given retention enema with Dahuang Baizhu constipation-relieving heavy prescription. Both groups were treated for 7 days. Results:The cure rate was 80.8% in the treatment group and 45.8% in the control group, compared the two groups, difference being significant(P < 0.05). The recovery time of intestinal sound,recovery time of exhaustion and defecation and relief time of abdominal pain in the treatment group were shorter than those in the control group,differences being significant(P < 0.05). At 7 and 14 days of treatment,the serum tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-8(IL-8) and C-reactive protein(CRP) levels in the two groups were lower than those at 1 day of treatment,differences being significant(P < 0.01);the levels of serum TNF-α,IL-6,IL-8 and CRP in the treatment group were lower than those in the control group, differences being significant(P < 0.01). Conclusion: The application of Dahuang Baizhuconstipation-relieving heavy prescription for early postoperative inflammatory intestinal obstruction can improve clinical symptoms and intestinal function and control inflammatory response.更多还原