【摘要】 目的研究神经生长因子(NGF)对高血压脑出血神经功能恢复的疗效及安全性。方法选择高血压脑出血患者48例,随机分为对照组和处理组,均为24例。对照组患者接受常规治疗,处理组患者在此基础上辅以NGF治疗。比较两组治疗前及治疗后2周、1月、6月的神经功能缺损评分(NIHSS)及日常生活活动能力评分(Barthel指数)。同时观察两组患者入院时、治疗后1个月的血常规及肝肾功能指标以评估NGF的安全性。结果处理组治疗1个月后的NIHSS评分及Barthel指数均明显优于对照组,差异均有统计学意义(t分别=2.45、2.53,P均<0.05)。两组患者入院时及治疗1个月后的白细胞、血小板、谷丙转氨酶、谷草转氨酶、肌酐比较,差异均无统计学意义(t分别=0.71、0.48、0.10、1.74、0.68;0.04、0.16、1.29、0.71、0.30,P均>0.05)。结论 NGF能够加速高血压脑出血患者的神经功能恢复,且是安全的。更多还原

【Abstract】 Objective To investigate the clinical efficacy and safety of nerve growth factor(NGF)on the patients with hypertensive intracerebral hemorrhage. Methods Forty-eight patients were randomly divided into two groups with twenty-four cases in each group. The patients in the control group received normal treatment,and patients in the treatment group received NGF on basis of normal treatment during the same period.Neurological functional defect score(NIHSS evaluation)and the daily life activity ability score(Barthel index)were collected and compared between the two groups before and after the treatment(two weeks,one month and six months). Parameters of CBC,liver and kidney function were also gained before and one month after the treatment to evaluate the safty. Results NIHSS scores and Barthel index scores of the treatment group were significantly better than those of the control group at one month after the treatment(t=2.45,2.53,P<0.05).The differences in white blood cells,platelets,glutamic pyruvic transaminase,glutamic oxaloacetic transaminase and creatinine between the two groups at the time of admission and one month after treatment were not statistically significant(t=0.71,0.48,0.10,1.74,0.68;0.04,0.16,1.29,0.71,0.30,P>0.05).Conclusion Nerve growth factor can improve the recovery of neurological function of patients with hypertensive intracerebral hemorrhage,which is also safe.更多还原