【摘要】 目的观察定痛方治疗血瘀痰结型肺癌高凝状态的疗效。方法使用随机对照方法,将80例肺癌患者按抽签方法随机分为2组,对照组40例,给予最佳对症支持治疗;治疗组40例,在最佳对症支持治疗基础上给予口服中药定痛方(瓜蒌15 g,法半夏10 g,浙贝母12 g,地龙10 g,郁金10 g,元胡15 g,炒白芍15 g,蜈蚣2条,蒲黄6 g,五灵脂6 g,天冬10 g,玉竹10 g)。水煎服,日1剂,以4周为一个治疗周期。通过检测治疗前后的血浆凝血酶原时间(PT)、血浆纤维蛋白原含量(FIB)、活化部分凝血活酶时间(APTT)及凝血酶时间(TT)、血小板(PLT)、D-二聚体等血液流变学指标,比较两组患者凝血功能的改善情况,且通过K氏评分(KPS)评估患者治疗前后生活质量改善情况。结果治疗组PT、APTT、FIB、PLT、D-二聚体水平明显低于对照组,差异有统计学意义(P<0.05),两组TT无明显差异(P>0.05)。患者治疗前后KPS,治疗组明显优于对照组,差异有统计学意义(P<0.05)。结论定痛方可显著改善血瘀痰结型肺癌高凝状态,并在一定程度上可提高患者生活质量。更多还原

【Abstract】 Objective To observe the curative effect of Dingtong Fang(Analgesic Formula) on hypercoagulable state in patients with lung cancer-blood stasis and phlegm binding. Methods The patients(n=80)were randomly divided into control group(n=40) treated with the optimal support therapy, and treatment group(n=40)were additionally treated with oral Dingtong Fang [Gualou(15 g), Fabanxia(10 g), Zhebeimu(12 g), Dilong(10 g),Yujin(10 g), Yuanhu(15 g), Chaobaishao(15 g), Wugong(2 pieces), Puhuang(6 g), Wulingzhi(6 g), Tiandong(10 g) and Yuzhu(10 g)] decocted in water, once a day and 4 weeks as a treatment cycle. The indexes of hemorrheology,including prothrombin time(PT), fibrinogen(FIB), activated partial thromboplastin time(APTT), thrombin time(TT), platelet(PLT) and D-dimer(DD), were detected in 2 groups before and after treatment. The amelioration of coagulation function was compared between 2 groups, and quality of life(QOL) was reviewed by using KPS scoring before and after treatment. Results The levels of PT, APTT, FIB, PLT and DD were significantly lower in treatment group than those in control group(P<0.05), and level of TT had no significant difference between 2 groups(P>0.05).The scores of KPS were superior in treatment group to those in control group(P<0.05). Conclusion Dingtong Fang can significantly meliorate hypercoagulable state and improve QOL in patients with lung cancer-blood stasis and phlegm binding.更多还原