【摘要】 目的:研究甲状腺超声血流指数(FI)与肿瘤恶性程度的关系。方法:选择2015年2月—2018年5月在我院接受手术切除的甲状腺癌患者和甲状腺腺瘤患者,分别作为观察组和对照组。术前进行甲状腺超声并测定FI,采集血清并测定肿瘤相关细胞角蛋白19片段(CYFRA21-1)、肿瘤相关物质(TAM)、基质金属蛋白酶9(MMP9)的含量;术后收集病灶并测定基因PCNA、Ki-67、Cyclin D1、p53、PTEN的表达水平。结果:观察组FI水平(43.12±6.62)明显高于对照组(33.41±6.62);观察组中AJCCⅢ～Ⅳ期、组织分化Ⅲ期、有颈淋巴结转移、有包膜浸润患者的FI水平明显高于AJCCⅠ～Ⅱ期、组织分化Ⅰ～Ⅱ期、无颈淋巴结转移、无包膜浸润患者(P<0.05);高FI甲状腺癌患者血清Cyfra21-1、TAM、MMP9含量以及病灶内PCNA、Ki-67、Cyclin D1的阳性表达率均明显高于低FI甲状腺癌患者,高FI甲状腺癌患者病灶内p53、PTEN的阳性表达率明显低于低FI甲状腺癌患者(P<0.05)。结果:甲状腺超声FI能够反应甲状腺癌的临床病理特征及恶性程度。更多还原

【Abstract】 Objective: To study the correlation between thyroid ultrasound blood flow index(FI and malignant degree of tumors. Methods: Patients with thyroid cancer and thyroid adenoma who underwent surgical resection in our hospital from February 2015 to May 2018 were selected as observation group and control group. Thyroid ultrasound were conducted and FI were measured before operation. Serum samples were collected and cytokeratin 19 fragments(CYFRA21-1) and tumo associated material(TAM) and matrix metalloproteinase 9(MMP9) levels were determined; the lesions were collected and the expression levels of PCNA, Ki-67, Cyclin D1, p53 and PTEN were determined. Results: The FI level of patients in the observation group was(43.12±6.62), which was significantly higher than(33.41±6.62) of the control group; the FI level of patients with AJCC III-IV stage, tissue differentiation III stage, cervical lymph node metastasis and capsular infiltration in the observation group was significantly higher than that of patients with AJCC I-II stage, tissue differentiation I-II stage, no cervical lymph node metastasis and no capsular infiltration(P<0.05). The serum levels of Cyfra21-1, TAM, MMP9 and the positive expression rates of PCNA, Ki-67 and Cyclin D 1 in high FI thyroid cancer patients were significantly higher than those in low FI thyroid cancer patients, and the positive expression rates of p53 and PTEN in lesions were significantly lower than those in low FI thyroid cancer patients(P<0.05). Conclusion: Thyroid ultrasound FI could reflect the clinicopathological features and malignant degree of thyroid cancer.更多还原