【摘要】 [目的]为三唑酮微胶囊的制备及三唑酮控制释放剂型的开发提供理论依据。[方法]以密胺树脂为壁材,采用原位聚合法制备三唑酮微胶囊,以包封率为评价指标,通过单因素法和响应面法优化试验,并研究了三唑酮微胶囊的物化性质。[结果]三唑酮微胶囊的最佳制备工艺为:以苯乙烯马来酸酐和十二烷基苯磺酸钠复配作为乳化剂,用量为0.82 g、壁材用量为14.43 g、反应初始温度20℃、转速800 r/min、反应的终点pH值为5、固化温度68℃、固化时间120 min,三唑酮微胶囊的包封率平均值可达85.31%,和预测模型值86.76%相比,相对误差仅为1.67%。[结论]响应面法能够有效的优化三唑酮微胶囊的制备工艺。更多还原

【Abstract】 [Aims] The aims were to provide theoretical basis for the preparation of triadimefon microcapsules and the development of controlled release formulations. [Methods] Triadimefon microcapsules were prepared via the in-situ polymerization method using melamine-formaldehyde(MF) as wall material. Single factor experiments and response surface methodology were employed to optimized the preparation condition based on embedding rate. The physicochemical properties of triadimefon microcapsules were investigated as well. [Results] Under the optimized conditions: the dosage of melamine-formaldehyde resin in the preparation was 14.43 g, emulsifier was SDBS and SMA and the dosage was 0.82 g. emulsifying stir-speed was 800 r/min, terminal pH was 5, and the solidifing temperature of the microcapsules with high encapsulation ratio was controlled at 68 ℃ for 120 min, the embedding rate could reach85.31%. A relative error was only 1.67% compared to the expected value(86.76%). [Conclusions] Response surface methodology can effectively optimize the preparation process of triadimefon microcapsules.更多还原