【摘要】 Lin28a和Lin28b是RNA结合蛋白,通过结合let-7 microRNA前体调控let-7的成熟过程,或直接与mRNA结合调控其翻译和稳定性,参与细胞多潜能性、肿瘤发生、葡萄糖代谢等多个生理过程。最近一些研究发现二者可能参与人和动物的生殖活动,但功能还不清晰。本文对Lin28a和Lin28b基因在哺乳动物初情期启动、原始生殖细胞(primordial germ cells, PGCs)形成和配子发生中的作用相关研究进行了综述,以期为深入探索二者在动物生殖中的功能研究提供参考。更多还原

【Abstract】 Lin28a and Lin28 b, as RNA-binding proteins, bind to the terminal loop of pri-and pre-let-7miRNA and repress their processing; also bind to target mRNA to modulate their translation, and mediate several physiological processes, such as cell pluripotency maintenance, tumorigenesis and glucose metabolism. Some new researches discovered that Lin28 a and Lin28 b may participate in human and animal reproduction, and the action mechanisms remain ill defined. The present paper reviews the research progress on the role of Lin28 a and Lin28 b genes in onset of mammalian puberty, primordial germ cell(PGCs)formation and gametogenesis, and provide some reference for further studies on their roles in animal reproduction.更多还原