【摘要】 制备具有显著抗菌活性的1-[(2-甲氧基-4-乙氧基)苯基]-3-[(3-(4-氧香豆素)苯基]硫脲。以4-氯香豆素为原料,经过醚化、异硫氰酸化和缩合反应合成目标化合物1-[(2-甲氧基-4-乙氧基)-苯基]-3-(3-(4-氧香豆素基)苯基)硫脲。在优化的条件下,反应总收率为61. 63%,纯度为99%,其结构经1HNMR分析确认。该化合物具有优良的抗菌活性,该工艺简单经济,条件温和。更多还原

【Abstract】 In order to synthesize 1-[( 2-methoxyl-4-oxethyl) Phenyl]-3-[( 3-( 3-( 4-Oxygencoumarin) phenyl) sulfocarbamide with significant antibacterial activity. The target compound was synthesized from 4-hydroxycoumarin via etherification,isothiocyanate and condensation reactions ’. The structure of synthesized compounds were confirmed by 1 H NMR,IR and GC-MS. The purity was found to be 99%,and the total yield of the three-step process was61. 63%. The compound has excellent antibacterial activity. The process is simple with mild manufacturing condition.更多还原