【摘要】 目的:探讨切除修复交叉互补基因1(excision repair cross complementing 1,ERCC1)2种最常见的基因多态性(rs3212986、rs11615)与胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)患病风险的相关性。方法:检索PubMed、EMBASE、Web of Science、中国知网文献数据库,查找国内外关于ERCC1多态性(rs3212986、rs11615)与PDAC易感性关系的病例对照研究。由2名评价者根据纳入标准分别独立筛选文献并提取数据后,采用Stata12.0软件进行Meta分析。结果:共纳入8项病例对照研究,其中ERCC1 rs3212986纳入4项研究共1 934例患者,rs11615纳入4项研究共2 547例患者。结果显示,ERCC1rs3212986可显著提高人群PDAC的患病风险(CA vs. AA:OR=1.34,95%CI:1.11～1.63;CC vs. AA:OR=2.33,95%CI:1.73～3.14;AC+CC vs. AA:OR=1.50,95%CI:1.25～1.80;CC vs. CA+AA:OR=1.98,95%CI:1.50～2.62;C vs. A:OR=1.45,95%CI:1.27～1.66);而ERCC1 rs11615则与PDAC患病风险无关(CT vs. TT:OR=1.02,95%CI:0.87～1.21;CC vs. TT:OR=1.21;95%CI:0.93～1.56;TC+CC vs. TT:OR=1.06,95%CI:0.91～1.24;CC vs. CT+TT:OR=1.20,95%CI:0.94～1.53;C vs. T:OR=1.08,95%CI:0.96～1.21)。结论:ERCC1 rs3212986可明显增加PDAC发病风险,rs11615则与PDAC易感性无关。更多还原

【Abstract】 Objective:This study aims to assess the association between excision repair cross complementing 1(ERCC1)gene polymorphisms(rs3212986、rs11615)and susceptibility to pancreatic ductal adenocarcinoma. Methods:Evidence for this association was obtained by searching PubMed,Web of Science,EMBASE and CNKI. Data were extracted using standardized forms and odds ratios(ORs)with 95% confidence intervals(CIs)were used to assess the strength of association. All statistical analyses were performed using Stata 12.0. Results:Eight studies were enrolled in our final combined analysis. The results showed evidence for significant association between rs3212986 polymorphism and PDAC risk(CA vs. AA:OR=1.34,95% CI:1.11-1.63;CC vs. AA:OR=2.33,95% CI:1.73-3.14;AC+CC vs. AA:OR=1.50,95% CI:1.25-1.80;CC vs. CA+AA:OR=1.98,95% CI:1.50-2.62;C vs. A:OR=1.45,95% CI:1.27-1.66).However,no association was observed between rs11615 and PDAC risk(CT vs. TT:OR=1.02,95% CI:0.87-1.21;CC vs. TT:OR=1.21;95% CI:0.93-1.56;TC+CC vs. TT:OR=1.06,95% CI:0.91-1.24;CC vs. CT+TT:OR=1.20,95% CI:0.94-1.53;C vs. T:OR=1.08,95%CI:0.96-1.21). Conclusion:The allele gene C of ERCC rs3212986 is significantly associated with the risk of PDAC,while rs11615 might not contribute to the risk of PDAC.更多还原