【摘要】 蒙脱石广泛应用于医药、化工、食品等领域,随着人们健康意识的不断增强,对《中国药典》中所规定的蒙脱石(散)的质量要求也随之提高,相应的企业对测试结果的稳定性和重复性也提出了新的要求.本实验中,使用X-射线粉末衍射仪(PXRD)考察了5种因素对蒙脱石鉴定以及方英石和其他杂质含量测定的影响.结果表明,(1)研磨不会破坏蒙脱石的晶型结构,用玛瑙研钵研磨3 min为宜.(2)相对湿度和温度对蒙脱石的第一个特征峰(5.7°左右)影响明显.相对湿度增大,向低角偏移,对应的晶面距增大;温度升高,向高角偏移,对应的晶面距减小,但不影响方英石和其他杂质的检测.(3)蒙脱石的预处理是将其置于温度20℃～25℃、相对湿度75%的环境条件下,静置12 h为最佳.(4)蒙脱石散前处理的溶解、洗涤、过滤是定量检测结果好坏的关键,建议至少洗涤6次.本实验结果为生产企业进行蒙脱石(散)定性定量分析提供了参考依据.更多还原

【Abstract】 Montmorillonite is widely used in medicine,chemical industry,food and other fields. With the increasing awareness of people’s health,the quality requirements of montmorillonite(powder)specified in the Chinese Pharmacopoeia have also increased. New requirements for the stability and repeatability of the test results are also placed on by the corresponding companies. In this experiment,the influence of five factors on the identification of montmorillonite,and the determination of cristobalite and the other impurity was investigated by X-ray powder diffractometer(PXRD). The results showed that,(1)The crystal structure of montmorillonite does not be destroyed by grinding,and it is suitable to grind with agate mortar for 3 min.(2)The effect of temperature and humidity on the first characteristic peak of montmorillonite(about 5.7°)is obvious. When the humidity increases,it shifts to a low angle,and the corresponding crystal face distance increases. When the temperature rises,it shifts to a high angle,and the corresponding crystal face distance decreases. They don’t affect the detection of cristobalite and other impurities.(3)It is suitable to place the montmorillonite under the environmental conditions of temperature 20 ℃～25 ℃ and relative humidity 75% for 12 h for pretreatment.(4)Dissolution,washing and filtration of montmorillonite pretreatment are the key to the quantitative detection results. It is recommended to wash at least 6 times. The results of this experiment provide a reference in the qualitative and quantitative analysis of montmorillonite(dispersion)for production enterprises.更多还原