【摘要】 目的探讨联合检测心型脂肪酸结合蛋白(H-FABP)、脑钠肽(BNP)诊断老年慢性心力衰竭(CHF)的临床价值。方法选择2015年7月～2016年6月医院收治的老年CHF患者89例,按照NYHA分级分为Ⅰ～Ⅱ级组(n=65)与Ⅲ～Ⅳ级组(n=24),选择同期进行健康体检的26例老年健康者作为对照组,3组性别、年龄差异无统计学意义(P>0.05)。检测比较3组BNP,H-FABP水平及左心房内径(LAD),左心室收缩末期内径(LVESd),左心室舒张末期内径(LVEDD),室间隔厚度(IVST)、左心室射血分数(LVEF)。分析BNP,H-FABP与LAD,LVESd,LVEDD,IVST,LVEF的相关性。结果Ⅰ～Ⅱ级组BNP,H-FABP水平与对照组及Ⅲ～Ⅳ级组比较,差异有统计学意义(P<0.05)。Ⅲ～Ⅳ级组与对照组比较,差异亦有统计学意义(P<0.05)。Ⅰ～Ⅱ级组LAD,LVESd,LVEDD,IVST与对照组及Ⅲ～Ⅳ级组比较,差异有统计学意义(P<0.05)。BNP,H-FABP与LAD,LVESd,LVEDD,IVST均呈正相关关系(P<0.05),与LVEF均呈负相关关系(P<0.05)。BNP与H-FABP呈正相关关系。结论联合检测BNP,H-FABP可准确诊断老年CHF并评估其严重程度。更多还原

【Abstract】 Objective To study the joint detection heart-type fatty acid binding protein,brain natriuretic peptide diagnosis of senile chronic heart failure value.Methods July 2015～June 2016 year of 89 cases of elderly CHF patients admitted to hospital in June,according to the NYHA classification is divided into Ⅰ～Ⅱ group and the Ⅲ～Ⅳ group,selected the period for health examination of 26 cases of senile in hospital health were included in the control group,three groups of no statistically significant differences in gender,age.Methods Comparison of three groups of BNP,H-FABP levels and left atrial diameter,left ventricular end diastolic diameter,left ventricular end diastolic diameter,ventricular septal thickness,left ventricular ejection fraction.Analysis BNP,H-FABP LAD,LVESd,LVEDD,IVST,and LVEF of relevance.Results BNP,H-FABP level Ⅰ～Ⅱ level group than in the control group,below the Ⅲ～Ⅳ level group differences are statistically significant(P<0.05).BNP,H-FABP level Ⅲ～Ⅳ level group than in the control group,a statistically significant difference(P<0.05).Ⅰ～Ⅱ grade IVST group LAD,LVESd,LVEDD,than in the control group,is less than the Ⅲ～Ⅳ level group,LVEF less than control group,is greater than the Ⅲ～Ⅳ group,a statistically significant difference(P<0.05).BNP and the H-FABP related to LAD,LVESd,LVEDD,IVST were positively related(P<0.05),and LVEF negative correlation(P<0.05).BNP was positively correlated with H-FABP.Conclusion The combined detection of BNP,H-FABP can accurately diagnose of senile chronic BNP and to assess their severity.更多还原