【摘要】 目的探讨术前中性粒细胞和淋巴细胞比值(NLR)、单核细胞和淋巴细胞比值(MLR)与宫颈癌临床病理特征的相关性。方法收集194例子宫良性肿瘤患者及194例宫颈癌患者的临床资料,分析治疗前1周内NLR、MLR水平与临床病理特征的相关性。结果宫颈癌患者术前NLR、MLR水平均高于子宫良性肿瘤患者(P <0.05)。在宫颈癌患者中,高NLR与低NLR 2组在FIGO分期、淋巴/脉管转移、病理分级、初婚年龄、产次方面的差异均有统计学意义(P <0.05),而高MLR与低MLR 2组在FIGO分期、淋巴/脉管转移、肌层浸润及初婚年龄差方面的异均有统计学意义(P <0.05)。结论 NLR与MLR可作为宫颈癌治疗前的常规筛查项目,在判断病情严重程度上具有一定的临床意义,有望成为临床预测宫颈癌患者预后的指标。更多还原

【Abstract】 Objective To explore the relationship between preoperative neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR) and clinical pathologic features of patients with cervical cancer.Methods The clinical data of 194 cases of benign uterus tumors and 194 patients with cervical cancer were collected. The NLR and MLR were calculated in patients one week before treatment, the relationship between NLR, MLR and clinical pathologic features were statistically analyzed. Results NLR and MLR levels in patients with cervical cancer were higher than those in benign uterus tumors(P < 0.05). For cervical cancer patients, the differences for FIGO staging, lymphatic vessel metastasis, pathological grading, first marriage age and parities were statistically significant between high NLR group and low NLR group(P < 0.05).Besides, there was a statistical significance in FIGO staging, lymphatic vessel metastasis, myometrial invasion and first marriage age between high MLR group and low MLR group(P < 0.05). Conclusion NLR and MLR could be used as a routine examination before treatment for cervical cancer, which possesses certain clinical significance for estimatingthe severity of the disease. They could be used as new indexes for predicting the prognosis of cervical cancer.更多还原