【摘要】 目的探讨血脂与1型糖尿病肾脏疾病（DKD）的关系。方法采用横断面回顾性研究177例1型糖尿病（T1DM）患者相关资料,按照尿白蛋白/尿肌酐比值（UACR）水平分为3组:正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组。结果 （1）与正常白蛋白尿组比较:大量白蛋白尿组三酰甘油、胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）均明显升高,P <0. 05;（2） TC与舒张压（DBP）、UACR、体质指数（BMI）呈正相关,与C肽水平呈负相关;高密度脂蛋白胆固醇与糖化血红蛋白（HbA₁c）呈负相关,与C肽呈正相关; LDL-C与DBP、UACR、HbA₁c、BMI呈正相关;极低密度脂蛋白胆固醇（VLDL-C）与年龄和UACR呈正相关。（3） logistic回归分析结果显示TC、LDL-C是影响DKD发生的独立危险因素。结论脂代谢异常参与T1DM患者DKD的发生和发展。更多还原

【Abstract】 Objective To analyze the relationship between lipid metabolism and urinary albumin/urinary creatinine ratio（ UACR）,and to evaluate the value of plasma lipid level in predicting the occurrence and development of diabetic kidney disease（ DKD） among type 1 diabetic patients（ T1DM）. Methods Based on retrospectively cross sectional study,177 patients with T1DM were enrolled in this study. Patients were divided into three groups according to UACR:normo-albuminuria group（ n = 115）,microalbuminuria group（ n = 46）,macroalbuminuria group（ n = 16）. Results（ 1） Levels of cholesterol（ TC）,triglyceride and low density lipoprotein cholesterol（ LDL-C） in macroalbuminuria group were higher than those in normo-albuminuria group（ P < 0. 05）.（ 2） The TC level had the positive correlation with diastolic pressure（ DBP）,body mass index（ BMI） and UACR,and had the negative correlation with serum C-peptide. High density lipoprotein cholesterol had the positive correlation with serum C-peptide,and had the negative correlation with glycosylated hemoglobin（ HbA₁c）. LDL-C had the positive correlation with DBP,UACR,HbA₁c and BMI. Very low density lipoprotein cholesterol had the positive correlation with age and UACR. Logistic regression analysis showed that TC and LDL-C were independent risk factors for DKD. Conclusions Impaired lipid metabolism is the independent risk factor of the occurrence and development of DKD in patients with T1DM.更多还原