【摘要】 目的探讨急性高血压性脑出血（AHCH）患者血清gaspase切割的细胞角蛋白18（CCCK-18）水平与预后的相关性分析。方法选取2016年1月至2018年4月在收集佛山市第一人民医院神经外科住院的AHCH患者70例作为观察组,另选取同期健康体检者30例作为对照组,比较两组血清CCCK-18水平,采用酶联免疫吸附法（ELISA）检测患者入院第1天血清CCCK-18水平;3个月后采用改良Rankin量表评分（mRS）评估患者的预后,分为预后良好亚组（mRS≤2分）和预后不良亚组（mRS>2分）,采用多因素Logistic回归方法分析影响患者预后的独立危险因素。结果观察组患者血清CCCK-18水平（245.47±52.84）U·L^-1明显高于对照组（81.90±35.73）U·L^-1,差异有统计学意义（t=15.483,P=0.000）。预后不良亚组NHISS评分、血肿体积、纤维蛋白原、D-二聚体、CCCK-18水平明显高于预后良好亚组,差异有统计学意义（P <0.05）。Logistic回归分析显示,NIHSS评分、血清CCCK-18是影响脑出血患者预后的独立危险因素。结论血清CCCK-18与AHCH患者的预后存在相关性。更多还原

【Abstract】 Objective To investigate the correlation analysis of serum caspase-cleaved cytokeratin-18（CCCK-18） level and prognosis of patients with acute hypertensive cerebral hemorrhage（AHCH）. Methods A total of 70 patients with AHCH enrolled in this study from January 2016 to April 2018 as observation group,and 30 healthy subjects were selected as control group. Serum CCCK-18 levels were compared between the two groups.Enzyme-linked immunosorbent assay（ELISA） was used to detect the level of serum CCCK-18 on the 1 st day after admission. According to the modified Rankin scale（mRS） at Three months after admission, patients were divided into good prognosis group（mRS ≤ 2 points） and poor prognosis group（mRS > 2 points）. Multivariate Logistic regression was used to analyze independent risk factors affecting prognosis. Results The serum CCCK-18 level in the observation group（245.47±52.84）U·L^-1 was significantly higher than that in the control group（81.90±35.73）U·L^-1, and the difference was statistically significant（t=15.483, P=0.000）. The NHISS score, hematoma volume,fibrinogen, D-dimer and CCCK-18 levels in the subgroup with poor prognosis were significantly higher than those in the subgroup with good prognosis（P < 0.05）. Logistic regression analysis showed that NIHSS score and serum CCCK-18 were independent risk factors for the prognosis of patients with cerebral hemorrhage. Conclusions There is a correlation between serum CCCK-18 and the prognosis of patients with AHCH.更多还原