【摘要】 目的探讨脊髓灰质炎后综合征(PPS)的临床表现及电生理特征,以利于该病的诊断水平。方法收集河北医科大学第二医院神经内科就诊的2例PPS患者的临床资料,分析该病的主要临床表现及电生理特点。结果例1患者7岁时患脊髓灰质炎,遗留右下肢短小。60年后出现缓慢进展的左下肢无力,肌肉萎缩;例2患者3岁时患脊髓灰质炎,遗留双下肢屈曲畸形,脊柱向右侧弯曲。47年后出现双上肢进行性无力,肌肉萎缩,疼痛,疲乏等表现,2例患者肌电图检查均以轻收缩时运动单位电位时限增宽及电位波幅增高为主,安静状态下自发电位少见。结论 PPS是脊髓灰质炎发病后,临床症状稳定多年后再次出现缓慢进展的迟缓性瘫痪,肌电图主要表现为慢性的神经再生过程。更多还原

【Abstract】 Objective To investigate the clinical manifestations and electrophysiological characteristics of post-poliomyelitis syndrome(PPS) in order to improve the diagnostic level of the disease. Method We collected the clinical data of 2 patients with PPS in Department of Neurology, Second Hospital of Hebei Medical University,and analyzed the main clinical manifestations and electrophysiological characteristics of the disease. Results One patient suffered from poliomyelitis at 7 years old, left lower limb was short. After 60 years, left lower limb became weakness and muscle atrophy slowly progressed. Another patient suffered from poliomyelitis at 3 years old, left lower limb flexion deformity, spinal curvature to the right side. After 47 years, the symptoms presented progressive weakness,muscle atrophy, pain and fatigue of both upper limbs. Chronic nerve regeneration(higher amplitudes, longer durations of the motor unit action potentials) was the main feature of electromyography in all patients, and progressive denervation(fibrillations, positive sharp waves) was rare. Conclusion PPS is a new, slow progressive flaccid paralysis after many years of poliomyelitis infection. Electrophysiological examination mainly shows chronic nerve regeneration.更多还原