【摘要】 目的分析缺血性心肌病心力衰竭(心衰)与阻塞型呼吸睡眠暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的关系。方法选择2015年9月至2018年5月在内蒙古自治区人民医院住院,诊断为缺血性心肌病心衰的患者65例为研究对象。依据是否合并OSAHS分组,45例合并OSAHS患者作为观察组,20例单纯缺血性心肌病心衰患者作为对照组,比较两组患者心功能、呼吸参数,并分析缺血性心肌病心衰与OSAHS之间的相关性。结果观察组患者心肌做功指数(Tei指数)、左心室射血分数(left ventricular ejection fraction,LVEF)、最低血氧饱和度、平均血氧饱和度、二氧化碳分压、纽约心脏协会(New York Heart Association,NYHA)心功能分级与对照组比较,差异均有统计学意义(P<0.05)。呼吸暂停低通气指数(apnea-hypopnea index,AHI)与Tei指数、二氧化碳分压正相关(r=0.706,P<0.05;r=0.658,P<0.05),与LVEF、最低血氧饱和度、平均血氧饱和度负相关(r=-0.700,P<0.05;r=-0.803,P<0.05;r=-0.751,P<0.05)。多元逐步回归分析结果发现,仅有Tei指数为AHI的影响因子,回归方程:AHI=0.89×Tei指数-0.45。结论 OSAHS与缺血性心肌病心衰之间存在显著相关性,Tei指数是评价缺血性心肌病心衰合并OSAHS患者病情的有效指标。更多还原

【Abstract】 Objectives To investigate the relationship between ischemic cardiomyopathy heart failure and obstructive sleep apnea hypopnea syndrome(OSAHS). Methods From September 2015 to May 2018 in the Inner Mongolia Autonomous Region People′s Hospital,65 patients with ischemic cardiomyopathy heart failure were divided into observation group(45 patients)and control group(20 patients)according to whether complicating with OSAHS. Results Tei index,left ventricular ejection fraction(LVEF),minimum oxygen saturation,mean oxygen saturation,carbon dioxide partial pressure and New York Heart Association(NYHA)heart classification were significantly different between the two groups(P<0.05). Apnea-hypopnea index(AHI)positively correlated with Tei index and partial pressure of carbon dioxide(r=0.706,P<0.05;r=0.658,P<0.05),and negatively correlated with LVEF,minimum oxygen saturation and mean oxygen saturation(r=-0.700,P<0.05;r=-0.803,P<0.05;r=-0.751,P<0.05). Multiple stepwise regression analysis showed that only Tei index was the influencing factor of AHI,and the regression equation was AHI = AHI=0.89×Tei index-0.45. Conclusions Significant correlation exists between OSAHS and ischemic cardiomyopathy heart failure. Tei index is an effective index to evaluate the condition of patients with ischemic cardiomyopathy heart failure complicated with OSAHS.更多还原