【摘要】 目的探讨凝血指标和癌胚抗原表达水平与小细胞肺癌患者生存的关系。方法于2009年1月～2012年6月,选取本院收治的120例小细胞肺癌患者,另选取同期行健康体检的志愿者100例为对照组,所有受检者均采集血液标本,测定癌胚抗原表达水平、凝血功能指标,比较肺癌组与对照组的癌胚抗原表达水平、凝血功能指标。针对小细胞肺癌患者进行为期5年的随访,根据其5年生存情况,剔除失访病例,将随访成功患者分为存活组、死亡组,在随访5年时测定、比较癌胚抗原表达水平、凝血功能指标,并分析其与小细胞肺癌患者远期生存的相关性。结果肺癌组的癌胚抗原表达水平、D-二聚体、纤维蛋白原水平均高于对照组(P <0.05),凝血酶原时间、活化部分凝血活酶时间均短于对照组(P <0.05);死亡组患者的癌胚抗原表达水平、D-二聚体、纤维蛋白原水平均高于存活组(P <0.05),其凝血酶原时间、活化部分凝血活酶时间均短于存活组(P <0.05);经相关性分析后得出,癌胚抗原表达水平、D-二聚体、纤维蛋白原水平与小细胞肺癌患者的远期生存之间呈负相关,而凝血酶原时间、活化部分凝血活酶时间与小细胞肺癌患者远期生存呈正相关。结论小细胞肺癌患者的血液状态普遍处于高凝状态,凝血功能指标、癌胚抗原表达水平与其远期生存密切相关,临床上可将凝血功能指标、癌胚抗原表达水平作为预测小细胞肺癌患者预后的参考指标。更多还原

【Abstract】 Objective To study the relationship between coagulation parameters and carcinoembryonic antigen(CEA) expression in patients with small cell lung cancer(SCLC). Methods From January 2009 to June 2012,120 patients with small cell lung cancer(SCLC) who were admitted to our hospital during that period were selected as the study object and set up as the lung cancer group and 100 healthy volunteers who underwent the physical examination in our hospital at the same time as the control group. We collected blood samples of all the subjects to determine the expression level of carcinoembryonic antigen,coagulation function index,and compared the expression level of carcinoembryonic antigen between lung cancer group and control group. Coagulation function index. The patients with small cell lung cancer were followed up for 5 years. According to their 5-year survival,the patients were divided into survival group and death group. The expression level of carcinoembryonic antigen(CEA) and coagulation function were measured and compared during 5 years follow-up. The expression level of carcinoembryonic antigen(CEA) was analyzed. Results The expression levels of carcinoembryonic antigen and fibrinogen in lung cancer group were higher than those in control group(P <0.05). The prothrombin time and activated partial thromboplastin time were shorter than those in the control group(P <0.05). The expression levels of carcinoembryonic antigen and fibrinogen in the dead group were higher than those in the survival group(P <0.05),and the prothrombin time was higher than that in the survival group. The activated partial thromboplastin time was shorter than that of survival group(P <0.05). The expression of carcinoembryonic antigen(CEA) and fibrinogen levels were negatively correlated with the long-term survival of patients with small cell lung cancer(SCLC) and prothrombin time(prothrombin time). The activated partial thromboplastin time was positively correlated with the longterm survival of patients with small cell lung cancer. Conclusion The blood status of patients with small cell lung cancer is generally in hypercoagulability and coagulation function index. The expression level of carcinoembryonic antigen is closely related to its long-term survival. The coagulation function index and carcinoembryonic antigen expression level can be used as a reference index to predict the prognosis of patients with small cell lung cancer.更多还原