【摘要】 目的 从三阴性乳腺癌(TNBC)患者病理、临床资料及原发癌灶影像学特征中探寻新辅助化疗病理完全缓解(pCR)的独立预测因子。方法回顾性采集2011年1月至2018年6月确诊的女性初发TNBC患者76例,所有患者均在完成新辅助化疗方案后行根治性手术治疗。采集所有入组病例的临床一般资料、原发癌灶影像学特征及术前空芯针穿刺标本的病理信息,并根据术后病理是否获得pCR进行分组。单因素分析采用χ~2检验对各相关参数进行组间比较,多因素分析采用Logistic回归分析,来获取TNBC新辅助化疗pCR的独立预测因子。结果76例入组病例,26例获得pCR,完全缓解率为34.21%。单因素分析显示,肿瘤浸润淋巴细胞表达、Ki67表达、临床分期以及肿瘤大小与pCR相关(P<0.05)。Logistic回归分析显示,肿瘤浸润淋巴细胞表达阳性以及Ki67高表达(≥40%)是pCR的独立预测因子。结论肿瘤浸润淋巴细胞表达阳性以及Ki67高表达(≥40%)是TNBC新辅助化疗pCR的独立预测因子。更多还原

【Abstract】 Objective To explore the independent predictors of pathological complete remission after neoadjuvant chemotherapy for triplenegative breast cancer(TNBC). Methods A total of 76 women with primary TNBC diagnosed in our hospital from January 2011 to June 2018 were retrospectively analysed. All the patients received radical surgery after completing neoadjuvant chemotherapy. Clinical general data, imaging features of primary cancer lesions and pathological information of preoperative core needle biopsy specimens were collected for all enrolled patients, and patients were divided according to whether pathological complete remission( pCR) were obtained after surgery. The relevant parameters were compared between groups using the Chi-square test. Logistic regression analysis was used for multivariate analysis to obtain independent predictors of pCR. Results 76 cases were enrolled, and 26 cases obtained pCR, the rate of pCR was 34.21%.There were significant intergroup differences in expression of tumor infiltrating lymphocytes, expression of Ki67, clinical stages and tumor size. Logistic regression analysis showed that positive expression of tumor infiltrating lymphocytes and high expression of Ki67( ≥40%) were independent predictors of pCR. Conclusion Positive expression of tumor infiltrating lymphocytes and high expression of Ki67( ≥40%) are independent predictors of pCR to TNBC neoadjuvant chemotherapy.更多还原