【摘要】 移取江水样500mL,加入50.0μg·L^-1内标混合溶液100μL,采用全自动固相萃取仪（装有ENVI TM-18固相萃取柱）进行富集净化,收集洗脱液,于40℃水浴氮吹至近干,用乙腈（1+1）溶液定容至1.0mL,采用超高效液相色谱-串联质谱法同时测定其中8种酚类内分泌干扰物的含量。以HSS T3色谱柱为固定相,以不同体积比的0.1%（质量分数）氨水和乙腈的混合液为流动相进行梯度洗脱,串联质谱分析中采用电喷雾负离子源和多反应监测模式。采用内标法定量,8种酚类内分泌干扰物的线性范围均为0.10～40.00μg·L^-1,检出限（3S/N）为0.008～0.096ng·L^-1。方法用于闽江水样的分析,加标回收率为80.0%～91.8%,回收量的相对标准偏差（n=6）为2.9%～12%。更多还原

【Abstract】 The river water sample（500 mL）was collected and 50.0μg·L^-1 mixed solution of internal standard（100μL）were added.Enrichment and purification were processed by the instrument of automated solid phase extraction with ENVI TM-18 solid phase extraction column.The collected eluate was evaporated to near dryness by N2-blowing at 40℃in the water bath and then made up to 1.0 mL with acetonitrile（1+1）solution.UHPLCMS/MS was applied to the simultaneous determination of 8 phenolic endocrine disrupting chemicals in the solution.HSS T3 chromatographic column was used as stationary phase,and the mixture of 0.1%（mass fraction）ammonia and acetonitrile mixed in different ratios was used as mobile phase in gradient elution.ESI-and multi-reactions monitor mode were adopted in MS/MS.Internal standard method was used for quantitative.Linearity ranges of the 8 phenolic endocrine disrupting chemicals were found in the same range of 0.10-40.00μg·L^-1 with detection limits（3 S/N）in the range of 0.008-0.096 ng·L^-1.The proposed method was applied to the analysis of the water sample of Minjiang River,giving values of recovery found by standard addition method and RSDs（n=6）of recovery amounts in the ranges of 80.0%-91.8% and 2.9%-12% respectively.更多还原