【摘要】 目的明确帕金森病(PD)患者剂末现象发生率和临床特征。方法横断面调查129例PD患者临床基本特征,在运动功能较好状态下用PD评分量表(UPDRS)评价运动功能;自主功能神经量表、PD睡眠量表、汉密尔顿抑郁量表、汉密尔顿焦虑量表(HAMA)、简易智力状态检查(MMSE)量表评价相应非运动症状; PD患者生活质量问卷-39(PDQ-39)量表评价近1个月健康生活质量。采用UPDRS-36项和剂末现象问卷(WOQ-9)判定剂末现象的发生及特点。结果①剂末现象发生率为51. 9%;②存在剂末现象患者中,非运动症状波动不单独出现;③多元线性回归分析,WOQ-9得分(P=0. 010)、HAMA得分(P=0. 028)和MMSE得分(P=0. 016)是PDQ-39综合指数的影响因素(R~2=0. 55,F=15. 28)。结论 PD患者剂末现象的发生率较高,其临床特点呈多样化和规律性,剂末现象是PD患者生活质量的重要影响因素。更多还原

【Abstract】 Aim To determine the incidence and clinical characteristics of wearing-off( WO)phenomena. Methods 129 PD patients were recruited into a cross-sectional study,and demographic characteristics and clinical histories were collected. SCOPA-AUT,PDSS,HAMD,HAMA and MMSE,and the health related quality of life during the past one month was assessed by PDQ-39. WO phenomena were determined by both UPDRS-36 item and the WOQ-9 questionnaire. Motor functions,non-motor symptoms and WO phenomena were assessed. Results ①The incidence of WO phenomena in our study was 51. 9%. ② Based on the clinical characteristics of WO phenomena,the fluctuation of non-motor symptoms did not exit alone. ③ Multivariate linear regression analysis showed that PDQ-39 SI was correlated with WOQ-9 score( P = 0. 010),HAMA score( P = 0. 028),and MMSE score( P = 0. 016)( R~2= 0. 55,F = 15. 28). Conclusion The incidence of WO phenomena is high and its clinical characteristics are diversified but regular. WO phenomena were an important influencing factor which greatly impact the health related quality of life of PD patients.更多还原