【摘要】 目的:探讨ABCB1基因多态性的6个单核苷酸位点多态性与重性抑郁障碍(MDD)的关系。方法:采用病例-对照方法,用高温连接酶检测反应法(LDR)分析292例MDD患者(MDD组)及与其性别、年龄相匹配的208名健康对照者(NC组) ABCB1基因6个多态性位点(rs1045642、rs2032583、rs2032582、rs2235040、rs1128503、rs2235015)基因型及等位基因频率,分析与MDD发病的关系。结果:两组间6个多态性位点的基因型频率差异无统计学意义; MDD组rs2032582及rs1128503位点T等位基因频率显著高于NC组(P均<0. 05); rs1045642-rs2032582构成单体型TG频率NC组显著高于MDD组(χ~2=9. 72,P <0. 05)。结论:ABCB1基因的多态性位点rs2032582、rs1128503以及rs2032582-rs1045642的TG单体型可能与MDD发病相关。更多还原

【Abstract】 Objective: To explore the relationship between ABCB1 gene polymorphisms and major depressive disorder( MDD). Method: With the case-control design,the genotype frequency and allele frequency in the 6 points including rs1045642,rs2032583,rs2032582,rs2235040,rs1128503,rs2235015 of ABCB1 gene were detected by ligase detection reaction( LDR) in 292 MDD patients( MDD group) and 208 gender,aged matched normal controls( NC group). The ABCB1 gene polymorphisms and major depressive disorder were in the ratio of age and gender. The relationship between ABCB1 gene polymorphisms and MDD was analyzed.Results: The genotype frequency in the 6 points of ABCB1 gene between the two groups had no significant difference. The T allele frequencies of rs2032582 and rs1128503 in MDD group were significantly higher than those in the NC group( all P < 0. 05). The frequency of TG haplotypes constituted by rs1045642 and rs2032582 in the NC group was significantly higher than that in the MDD group( χ~2= 9. 72,P < 0. 05). Conclusion:The polymorphism of the points rs2032582 and rs1128503 of ABCB1 gene and TG haplotypes constituted by rs1045642 and rs2032582 may be related with the MDD.更多还原