【摘要】 肝纤维化是慢性肝病发展至肝硬化的必经阶段,肝硬化是各种慢性肝病的终末期改变,其早期诊断对及时治疗和预后非常重要。目前,肝纤维化和肝硬化的诊断方法主要包括肝活组织检查、超声、CT和MRI等。肝活组织检查是诊断肝纤维化及肝硬化程度的金标准,但由于其侵袭性及样本误差,临床应用受到限制。常规的非侵入性措施不能满足肝纤维及肝硬化的诊断要求。因此,寻找一种新的肝纤维化及肝硬化血清学标志物已成为研究热点。相关研究表明,血清高尔基体蛋白73是一种可用于肝纤维化及肝硬化诊断的血清标志物,有较大的临床应用价值。对目前临床上常用的肝纤维化和肝硬化诊断方法进行了陈述,并阐述了高尔基体蛋白73的生物学特征及其在肝纤维化及肝硬化诊断中的价值。更多还原

【Abstract】 Liver fibrosis is a necessary stage in the development of chronic liver diseases to liver cirrhosis. Liver cirrhosis is the end-stage change of various chronic liver diseases,and early diagnosis of liver fibrosis has an important value in timely treatment and prognosis. At present,liver biopsy,ultrasound,computed tomography,and magnetic resonance imaging are the main diagnostic methods for liver fibrosis and cirrhosis. Liver biopsy is the gold standard for the diagnosis of liver fibrosis and cirrhosis,but its clinical application is limited by invasiveness and sample error. Conventional noninvasive methods cannot meet the requirements for the diagnosis of liver fibrosis and cirrhosis.Therefore,searching for new serological markers for liver fibrosis and cirrhosis has become a research hotspot. Related studies have shown that serum Golgi protein 73(GP73) can be used as a serum marker for the diagnosis of liver fibrosis and cirrhosis and has high clinical value. This article reviews the commonly used methods for the diagnosis of liver fibrosis and cirrhosis and elaborates on the biological characteristics of GP73 and its value in the diagnosis of liver fibrosis and cirrhosis.更多还原