【摘要】 目的探讨实时三维超声血管斑块定量分析(VPQ)技术在评价颈动脉斑块所致血管狭窄程度中的临床应用价值。方法选取102例颈动脉斑块患者共130处颈动脉斑块,应用实时三维超声VPQ技术测定颈动脉内中膜厚度、最窄处斑块厚度、面积狭窄率、标化壁指数(NWI)及斑块回声强度,根据局部面积狭窄率判定颈动脉狭窄程度,并与CTA所测颈动脉狭窄程度进行对照。结果实时三维超声VPQ测得颈动脉局部管腔轻度狭窄15处、中度狭窄78处,重度狭窄37处;CTA测得颈动脉局部管腔轻度狭窄11处,中度狭窄71处,重度狭窄48处。实时三维超声与CTA对颈动脉斑块所致管腔狭窄程度的一致性检验为Kappa=0.765;实时三维超声VPQ技术测得颈动脉不同狭窄程度者间NWI值两两比较差异均有统计学意义(均P<0.05),其余参数比较差异均无统计学意义。结论实时三维超声VPQ分析技术能够准确测定颈动脉斑块所致血管狭窄程度,并可对相关指标进行量化分析,具有重要的临床应用价值。更多还原

【Abstract】 Objective To explore the clinical value of real-time three-dimensional ultrasound(RT-3DU)vascular plaque quantification(VPQ)technology in evaluating the degree of carotid stenosis.Methods One hundred and two patients with 130 carotid plaques were selected. RT-3DU VPQ technology for off-line analysis was applied to assess the carotid stenosis,the thickness of intima-media,the thickness of plaque of the narrowest vessel,normalized wall index(NWI)and the echo intensity of plaque. The degree of carotid stenosis was estimated according to area narrowing rate and compared with that detected by CTA.Results RT-3DU showed mild stenosis in 15 cases,moderate stenosis in 78 cases and severe stenosis in37 cases.CTA showed mild stenosis in 11 cases,moderate stenosis in 71 cases and severe stenosis in 48 cases. Detection of RT-3DU and CTA for carotid stenosis had a high consistency(Kappa=0.765).There was significant difference of NWI among different degree of carotid stenosis patients by RT-3DU VPQ. There were no significant difference of other parameters.Conclusion RT-3DU VPQ technology can be used to determine the degree of carotid stenosis precisely and be capable of quantitative analysis of related indexes. The clinical value of this technique is important.更多还原