【摘要】 刺激响应型材料作为智能材料的一个重要分支已经成为众多领域中极为重要的一部分.刺激响应型智能发光材料是指光学性质能够对外界环境的物理或化学信号做出响应的材料.外界条件的刺激主要包括光、热、pH、电场、磁场、力、分子等.基于稀土离子的智能发光材料由于其独特的光学性质,比如较窄的发射峰宽度、较长的发光寿命、较大的斯托克斯位移等,在化学、生物学、逻辑学展现了极为丰富的应用潜力.近年来,通过对分子结构及纳米材料的设计得到的具有刺激响应性的稀土智能发光材料在光学信息存储、生物传感、成像及药物递送等方面都吸引了研究者的广泛关注.本文概括了近年来刺激响应型稀土智能发光材料在光学编码及生物医学领域中的应用,并展望了这种智能发光材料的应用前景.更多还原

【Abstract】 As an important branch of smart materials, stimuli-responsive materials have become a significant part in a wide range of fields with the development of science and technology. Among them, stimuli-responsive smart luminescent materials refer to a type of materials whose optical properties could respond to the physical or chemical stimuli of the external environment, including photo-, thermo-, pH-, magnetic-, electric-, mechanical-and molecule-responsive. These stimuliresponsive smart materials could be utilized to design sensitive sensors, detectors and fluorescent probes for wide applications in optical encoding, biosensing, medical diagnosis and treatment. Featuring unique optical properties,including narrow emission band, long lifetime, large Stokes shift and excellent photostability, rare-earth ions have acted as ideal luminescence centers for fabricating smart luminescent materials and thus showing great application potential in chemistry, biology and logic. In recent years, through rational design of structures and compositions of organic molecules and nanomaterials, a variety of stimuli-responsive rare-earth doped smart luminescent materials could be obtained and have attracted extensive attention in optical encoding, biosensing, vivo imaging and drug delivery. In this review, the advances of stimuli-responsive rare-earth based smart luminescent materials in optical encoding and biomedicine are summarized according to the types of external stimuli. Conventional optical information storage is generally constrained by limited pathways, such as excitation wavelength, emission color and intensity. However, there are certain risks that these parameters would be reproduced easily. Based on this, studies on stimuli-responsive optical properties contribute to introduce new parameters for multi-modes optical encoding. This strategy has greatly improved information storage capacity and security. Moreover, researches on rare-earth luminescence lifetime provides a new dimension for optical encoding. Stimuli-responsive luminescent lifetime τ could be exploited to code information. Development of time-gated(TG) luminescence imaging technology further facilitated the lifetime-encoding study. TG luminescence imaging could differentiate compositions with different lifetimes at the same wavelength and greatly broadens the scope for optical multiplexing encoding. In the field of biology, systems can greatly improve the signal-to-noise ratio of imaging and the accuracy of treatment for precise nanomedicine, which facilitates reducing side effects. With the rapid development of rare earth nanomaterials, their unique optical and magnetic properties have also been used in bioimaging. In addition to being used as imaging agents, they are also widely used as therapeutic agents. Functional modification further expands the application of rare earth nanomaterials in nanomedicine. Combined with the stimuli-responsive strategy, rare-earth based smart nanomaterials have greater potential in theranostics. In the review, we mainly introduced the cancer diagnosis and treatment application of rare-earth nanomaterials stimulated by tumor microenvironment. The advances of stimuliresponsive rare-earth based smart luminescent materials in optical encoding and biomedicine are summarized and the future of this smart material is highlighted. Moreover, the future of this kind of smart materials is highlighted.更多还原