【摘要】 目的:研究eya4蛋白在口腔鳞状细胞癌(OSCC)中的表达及其意义。方法:免疫组织化学染色的方法检测eya4在60例OSCC患者的口腔黏膜组织和20例正常口腔黏膜组织(NOM)中的表达情况。结果:eya4在NOM组织以及高分化的OSCC组织中高表达,表达率分别为100%及95%,而在低分化的OSCC组织中表达率仅为5%,这表明eya4可能参与OSCC疾病发生发展的过程;此外通过研究eya4的表达与各项临床病理参数的关系显示,其表达情况与患者的年龄性别无关,而与肿瘤是否伴有淋巴结转移呈负相关即伴有淋巴结转移的病例中eya4表达水平明显低于不伴有淋巴结转移的患者。结论:eya4蛋白可能参与OSCC的疾病发生发展过程及转移过程。更多还原

【Abstract】 Objective: To study the expression and significance of eya4 protein in oral squamous cell carcinoma(OSCC). Methods: The expression of eya4 in oral mucosa of 60 patients with OSCC and 20 controls with normal oral mucosa(NOM) were detected by immunohistochemical staining. Results: Statistical analysis showed that eya4 was highly expressed in NOM tissues and highly differentiated OSCC squamous cell carcinoma tissues, with expression rates of 100% and 95%, respectively, while expression rate was only 5% in poorly differentiated OSCC squamous cell carcinoma tissues. This indicated that eya4 might be involved in the development of OSCC disease. In addition, by studying the relationship between the expression of eya4 and various clinicopathological parameters, the expression was not related to the age and sex of the patient. However, the eya4 expression levels were significantly lower in patients with lymph node metastasis than in patients without lymph node metastasis. Conclusion: Eya4 may influence the occurrence, development, and metastasis of OSCC.更多还原