【摘要】 目的探讨血栓弹力图(TEG)与常规凝血功能检测在肺癌患者凝血功能中的临床应用价值。方法选择2017年9月至2018年6月在该院确诊的45例肺癌患者作为肺癌组,选择同期40例健康体检者作为对照组,入院后分别进行TEG、常规凝血功能及血常规检测,并对检测结果进行分析。结果肺癌组凝血反应时间(R值)、血凝块形成时间(K值)、抗凝血酶Ⅲ(AT-Ⅲ)、活化部分凝血活酶时间(APTT)低于对照组,凝血形成速率(Angle角)、最大振幅(MA值)、凝血指数(CI值)、纤维蛋白原(FIB)、D-二聚体(DD)、纤维蛋白原降解产物(FDP)高于对照组,差异均有统计学意义(P<0.05);两组凝血酶原时间(PT)、凝血酶时间(TT)、血小板计数(PLT)差异均无统计学意义(P>0.05)。R值与APTT呈正相关(P<0.05);R值与DD呈负相关(P<0.05);K值与FIB、PLT均呈负相关(P<0.05);Angle角、MA值、CI值均与FIB、PLT呈正相关(P<0.05);MA值、CI值与AT-Ⅲ呈负相关(P<0.05)。结论肺癌患者TEG参数和常规凝血功能指标水平异常,即血液处于高凝状态;TEG参数与常规凝血功能指标和PLT存在明显相关性,但不能相互替代,提示检测TEG和常规凝血功能可及时为肺癌患者的凝血状况评估提供试验依据。更多还原

【Abstract】 Objective To investigate the clinical application evaluation of thrombelastogram(TEG)and routine coagulation function detection in the coagulation function of the patients with lung cancer.Methods Forty-five cases of lung cancer diagnosed in this hospital from September 2017 to June 2018 were selected as the lung cancer group and contemporaneous 40 people undergoing the healthy physical examination were selected as the control group.After admission,the TEG detection,routine coagulation function detection and blood routine detection were carried out respectively.Then the detection results were analyzed.Results The coagulation reaction time(R value),blood clot formation time(K value),AT-Ⅲ and APTT of the lung cancer group were lower than those of the control group.The coagulation formation velocity(Angle angle),maximal amplitude(MA value),coagulation index(CI value),FIB,DD and FDP in the lung cancer group were all higher than those in the control group,and the difference was statistically significant(P<0.05).PT,TT and PLT had no statistical difference between the two groups(P>0.05).The R value was positively correlated with APTT(P<0.05);the R value was negatively correlated with DD(P<0.05);the K value was negatively correlated with FIB and PLT(P<0.05).Angle angle,MA value and CI value were positively correlated with FIB and PLT(P<0.05);the MA value and CI value were negatively correlated with AT-Ⅲ(P<0.05).Conclusion The TEG parameters and the routine coagulation function indexes in the patients with lung cancer are abnormal,that is,the blood is in the state of hypercoagulability,and the TEG parameters are closely correlated to the conventional coagulation function indexes and PLT,but can not be replaced by each other.It is suggested that the detection of TEG and the routine coagulation function can provide the experimental basis for the assessment of the coagulation status of the patients with lung cancer in time.更多还原