【摘要】 目的探讨自然杀伤细胞、CD19+对乳腺癌患者保乳手术治疗后复发的预测价值。方法将辽宁省肿瘤医院自2015年5月至2017年5月收治的67例行保乳手术治疗的乳腺癌患者纳入B组,将60例同期入院健康体检者纳入A组。比较A组与B组术前、术后患者CD19+、自然杀伤细胞的表达水平;对B组患者进行为期1年的随访,比较A组与B组未复发、复发患者CD19+、自然杀伤细胞的表达水平;绘制受试者工作特征曲线(ROC曲线),判断自然杀伤细胞、CD19+对乳腺癌患者保乳手术治疗后复发的预测价值。结果 B组患者术前、术后CD19+、自然杀伤细胞表达水平均高于A组,差异有统计学意义(P<0.05);B组患者术后CD19+、自然杀伤细胞表达水平均低于术前,差异有统计学意义(P<0.05)。B组未复发、复发患者CD19+、自然杀伤细胞表达水平均高于A组,差异有统计学意义(P<0.05);B组未复发患者CD19+、自然杀伤细胞表达水平均低于复发患者,差异有统计学意义(P<0.05)。CD19+预测乳腺癌复发的灵敏度、特异度分别为80.31%、74.21%;自然杀伤细胞预测乳腺癌复发的灵敏度、特异度分别为60.02%、87.69%。结论自然杀伤细胞、CD19+表达水平升高对乳腺癌及其术后复发具有一定的预测价值。更多还原

【Abstract】 Objective To investigate the predictive value of natural killer cells and CD19+ in breast cancer patients after breast conserving surgery.Methods A retrospective study was performed on 67 cases of patients who underwent breast-conserving surgery who were admitted from May 2015 to May 2017.The 67 patients were divided into the Group B,the other 60 healthy volunteers were divided into the Group A.The expression levels of CD19+ and natural killer cells in preoperative and postoperative patients in Group A and Group B were compared.Patients in Group B were followed up for one year,and the expression levels of CD19+ and natural killer cells were compared between Group A and Group B.The receiver operating characteristic curve(ROC) was drawn to determine the predictive value of natural killer cells and CD19+ in breast cancer patients with recurrence after breast conserving surgery.Results The expression levels of CD19+ and natural killer cells in Group B were higher than those in Group A before and after surgery,and the differences were statistically significant(P< 0.05).The expression levels of CD19+ and natural killer cells in Group B patients after surgery were lower than those before surgery(P<0.05).The expression levels of CD19+ and natural killer cells in patients with no recurrence and recurrence in Group B were higher than those in Group A(P<0.05).The expression levels of CD19+ and natural killer cells in patients without recurrence in Group B were lower than those in patients with recurrence(P<0.05).The sensitivity and specificity of CD19+ in predicting breast cancer recurrence were 80.31% and 74.21%,respectively.The sensitivity and specificity of natural killer cells in predicting breast cancer recurrence were 60.02% and 87.69%,respectively.Conclusion Elevated expression levels of natural killer cells and CD19+ have certain predictive value for breast cancer and its postoperative recurrence.更多还原