【摘要】 目的探讨老年急性髓系白血病淋巴细胞亚群分布特点,及对预后影响。方法选取2015年1月—2018年10月在我院救治的老年急性髓系白血病患者80例作为研究对象,回归分析所有患者的临床资料,总结淋巴细胞亚群分布特点及对预后的影响。结果四种分型中淋巴细胞亚群占比比较,差异不具有统计学意义(P> 0.05);影响预后效果的危险因素主要有:FLT3-ITD突变阳性、初次诱导达到CR、年龄、CD3~+、CD4~+、白细胞计数;另外,经过治疗OR组患者CD3~+、CD4~+、CD4~+/CD8~+水平高于NR组,差异具有统计学意义(P <0.05);OR组患者CD8~+略低于NR组,对比差异无统计学意义(P> 0.05)。结论急性髓系白血病老年患者淋巴细胞亚群增高,会抑制患者的免疫功能,所以利用淋巴细胞亚群特点能分析评估出患者的预后效果。更多还原

【Abstract】 Objective To investigate the distribution of lymphocyte subsets in elderly patients with acute myeloid leukemia and its influence on prognosis. Methods 80 elderly patients with acute myeloid leukemia treated in our hospital from January 2015 to October 2018 were studied. The clinical data of all patients were analyzed retrospectively, and the distribution characteristics of lymphocyte subsets and their influence on prognosis were summarized. Results There was no significant difference in the proportion of lymphocyte subsets among the four types(P > 0.05). The main risk factors affecting the prognosis were FLT3-ITD mutation positive, CR, age, CD3~+, CD4~+, white blood cell count in the first induction. In addition, the levels of CD3~+, CD4~+, CD4~+/CD8~+ in the OR group were higher than those in the NR group, and the difference was statistically significant(P < 0.05). CD8~+ in OR group was slightly lower than that in NR group, with no significant difference(P > 0.05). Conclusion The increase of lymphocyte subsets in elderly patients with acute myeloid leukemia can inhibit the immune function of the patients, so the prognosis of the patients can be evaluated by the characteristics of lymphocyte subsets.更多还原