【摘要】 目的探讨N-cadherin、MT1-MMP、ADAM17在甲状腺癌中的表达及其意义。方法选取2016年1月-2017年12月期间医院行手术治疗的103例甲状腺癌患者术后甲状腺癌组织标本为观察组,另选取同期在我院行活检的65例结节性甲状腺肿病灶旁正常甲状腺组织标本为对照组,并分别监测观察组和对照组患者N-cadherin、MT1-MMP、ADAM17表达情况,并与甲状腺癌患者临床病理特征进行比较和分析。结果观察组患者N-cadherin、MT1-MMP、ADAM17的阳性表达率明显高于对照组,差异具有统计学意义(P<0.05)。Ⅲ～Ⅳ期患者N-cadherin、MT1-MMP、ADAM17的阳性表达率明显高于Ⅰ～Ⅱ期,差异具有统计学意义(P<0.05)。浸及浆膜患者N-cadherin、MT1-MMP、ADAM17的阳性表达率明显高于未及浆膜,差异具有统计学意义(P<0.05)。分化程度为低分化患者N-cadherin、MT1-MMP、ADAM17的阳性表达率明显高于中、高分化,差异具有统计学意义(P<0.05)。发生肝脏转移患者N-cadherin、MT1-MMP、ADAM17的阳性表达率明显高于未发生肝脏转移,差异具有统计学意义(P<0.05)。发生淋巴结转移患者N-cadherin、MT1-MMP、ADAM17的阳性表达率明显高于未发生淋巴结转移,差异具有统计学意义(P<0.05)。结论 N-cadherin、MT1-MMP、ADAM17在甲状腺癌的发生和发展中发挥重要作用,同时对于判断病情和预后亦具有十分重要的参考价值。更多还原

【Abstract】 Objective To explore the expression and significance of N-cadherin,MT1-MMP and ADAM17 in thyroid cancer.Methods The specimens of thyroid cancer were selected from the observation group of 103 patients with thyroid cancer who underwent surgery from January 2016 to December 2017. During the same time,normal thyroid tissue specimens of 65 nodular goiter undergoing biopsy in the hospital were selected as the control group. The expression of N-cadherin,MT1-MMP and ADAM17 were detected in observation group and control group and compared with the clinicopathological features of thyroid cancer patients. Results The positive expression rates of N-cadherin,MT1-MMP and ADAM17 in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05). The positive expression rates of N-cadherin,MT1-MMP and ADAM17 in patients with stage Ⅲ～Ⅳ were significantly higher than those in patients with stage Ⅰ～Ⅱ,the differences were statistically significant(P<0.05). The positive expression rates of N-cadherin,MT1-MMP and ADAM17 in patients with serosa impregnation were significantly higher than the those in patients without serosa impregnation,the differences were statistically significant(P<0.05). The positive rate of N-cadherin,MT1-MMP and ADAM17 in patients with poorly differentiated were significantly higher than those in patients with moderately and highly differentiated,the differences were statistically significant(P<0.05). The positive expression rates of N-cadherin,MT1-MMP and ADAM17 in patients with liver metastasis were significantly higher than those in patients without liver metastasis,the differences were statistically significant(P<0.05). The positive expression rates of N-cadherin,MT1-MMP and ADAM17 in patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis,the differences were statistically significant(P<0.05). Conclusions N-cadherin,MT1-MMP and ADAM17 play an important role in the occurrence and development of thyroid cancer and have an important reference value for judging the disease condition and prognosis.更多还原